ArticleFrontiers in oncology2025
Multicenter prospective cohort study on colorectal adenoma recurrence and malignant transformation risk based on integrative medicine: a study protocol.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06136026 (Integrative Chinese and Western Medicine for Colorectal Cancer), which is not on this map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrative Chinese and Western Medicine for Colorectal Cancer: A Nationwide Prospective Cohort Study
Who cites it
3 citing papers in PubMed.
- Clinical applications of gut microbiome for non-invasive diagnosis of colorectal neoplasia.Journal of gastroenterology · 2026Article
- Noninvasive diagnosis of colorectal adenoma: The emerging potential of blood-based biomarkers.World journal of gastroenterology · 2026Review
- Development and Internal Validation of a LASSO-Based Prediction Model for Colorectal Adenoma Recurrence After Polypectomy.Cancer management and research · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Colorectal adenoma (CRA), the main precursor of colorectal cancer (CRC), has a high recurrence rate (5-year cumulative: 48 - 68%) and a malignant transformation risk (0.2 - 0.5%). Traditional Chinese Medicine (TCM) provides a potential method to improve risk assessment and prevention. Based on TCM theories and the characteristics of colorectal adenoma, we hypothesize that an integrated system combining TCM syndromes, constitution types, and modern medical parameters can better predict adenoma recurrence and CRC occurrence. Methods and analysis: This is a multicenter prospective cohort study. A total of 15,000 patients with colonoscopy-confirmed colorectal adenomas will be recruited from 12 tertiary hospitals in China. At baseline, TCM characteristics (syndromes, constitution, tongue and pulse features), endoscopic findings, and biological samples (tongue coating, saliva, stool, blood, tissue) will be collected. The participants will be followed up for 5 years with risk-stratified standardized colonoscopy intervals. The primary outcomes are adenoma recurrence and CRC occurrence. The secondary outcomes include identifying risk factors and developing a predictive model. Multivariable logistic regression, Cox models, and mixed-effects models will be used for data analysis. A comprehensive biobank will be established to support future mechanistic studies. Ethics and dissemination: Ethical approval has been obtained from the Institutional Review Board of the Affiliated Hospital of Nanjing University of Chinese Medicine. Written informed consent will be obtained from all participants, who can withdraw at any time without prejudice. Clinical trial registration: https://clinicaltrials.gov/study/NCT06136026, identifier NCT06136026.
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