ArticleExperimental and therapeutic medicine2026
Diagnostic significance of the checkpoint kinase 1 gene in high-grade gastroenteropancreatic neuroendocrine neoplasms.
Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasms (HG-GEP NENs) primarily relies on histopathological differentiation and mitotic count assessment. Due to interobserver variability in morphological evaluation, reliable molecular diagnostic biomarkers are needed to support accurate classification, particularly in challenging cases where the distinction between well-differentiated neuroendocrine tumours grade 3 (NET G3) and poorly differentiated neuroendocrine carcinoma (NEC) is ambiguous. The present study aimed to identify clinicopathological markers that facilitate the differential diagnosis of HG-GEP NENs. A total of 34 patients with HG-GEP NENs were included in study. Integrated bioinformatics analysis, including protein-protein interaction network construction from the GSE211485 dataset and subsequent validation using The Cancer Genome Atlas data, identified checkpoint kinase 1 (
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