Evidence map›Paper›PMID 41220828›Full record

ArticleERJ open research2025

COPD exacerbation purulence status and its association with pulmonary embolism: a systematic review with meta-analysis.

Vicky Mai, Laura Girardi, Kerstin de Wit, Lana A Castellucci, Shawn Aaron, Francis Couturaud, Dean A Fergusson, Grégoire Le Gal

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Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vicky MaiDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Laura GirardiDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Kerstin de WitDepartment of Emergency Medicine and Medicine, Queen's University, Kingston, ON, Canada.
Lana A CastellucciDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Shawn AaronDepartment of Medicine, Faculty of Medicine, Division of Respirology, University of Ottawa, Ottawa, ON, Canada.
Francis CouturaudINSERM U1304-GETBO, CIC INSERM 1412, Univ_Brest, Département de Médecine Interne et Pneumologie, CHU_Brest, FCRIN INNOVTE, Brest, France.
Dean A FergussonDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Grégoire Le GalDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-9253-248X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diagnosing pulmonary embolism (PE) in patients with acute exacerbation of COPD (AECOPD) is challenging. Finding predictors of PE could help improve diagnostic management of patients with AECOPD. The aim was to evaluate the association between AECOPD purulence status and the presence of PE. Methods: A systematic review with meta-analysis was conducted. Medline, Embase and CENTRAL were searched from inception to April 2024 for randomised trials, cohort or cross-sectional studies reporting on the prevalence of PE according to AECOPD purulence status. Relative risks with 95% confidence intervals of PE according to AECOPD purulence status and pooled proportions of PE with their 95% confidence intervals were calculated according to AECOPD purulence status. Results: From 7059 citations identified, 14 studies (5056 participants) were included. The prevalence of PE varied between 0.4% and 33.2% across studies. The relative risk of PE was not statistically significantly lower in patients with purulent AECOPD compared to patients with nonpurulent/unknown aetiology AECOPD (relative risk 0.64, 95% CI 0.26-1.55; I Conclusion: The relative risk of PE was lower, but not statistically significant, in patients with purulent AECOPD compared to patients with nonpurulent/unknown aetiology AECOPD. Further studies are needed to confirm the association between PE and AECOPD purulence status and to assess its potential role in predicting PE.

Identifiers

PMID41220828
PMCPMC12598610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.