ArticleIEEE journal of translational engineering in health and medicine2025
An Adaptable Phase-Tracking System for Parkinsonian Rest Tremor: Design and In-Clinic Feasibility.
Article in IEEE journal of translational engineering in health and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundTremor is the most common movement disorder and a prevalent symptom of neurodegenerative conditions such as Parkinson's disease (PD). Given the limitations of medication, which may not effectively treat tremor, and the limited availability of surgical treatments such as deep brain stimulation, there is a pressing clinical need for non-invasive therapeutic alternatives, including peripheral electrical stimulation. The high variability of PD tremor poses a challenge to such therapies and calls for person-specific stimulation parameters.
methodsWe developed a wrist-worn system incorporating an adaptable phase-tracking algorithm designed for real-time estimation of Parkinsonian rest tremor phase. The algorithm dynamically adapts to tremor variability, including changes in the axis of maximum excursion and center frequency. The system was first validated offline, followed by in-clinic feasibility testing in three individuals with PD. The system triggered the delivery of both phasic and open-loop electrical stimulation to the participant's wrist.
resultsRobust phase estimation was achieved both offline and in all participants. The system adapted to changes in tremor dominant axis and center frequency. Modest tremor modulation was observed at select person-specific settings.
conclusionThis work provides a novel platform for research involving tremor phase tracking, accounting for PD tremor variability, and a foundation for developing personalized, non-invasive tremor management strategies. Clinical and Translational Impact Statement-This study presents a wearable system for adaptive tremor phase tracking validated in individuals with Parkinson's disease and establishes a foundation for further development of personalized non-invasive tremor management strategies. Category: Clinical Research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.