ArticleClinical ophthalmology (Auckland, N.Z.)2025
Pericentral Scotometry Guided by Standard Perimetry Using Microperimetry in Glaucoma Patients.
Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To evaluate whether regionally customized high-density MP-3 microperimetry guided by regions of interest (ROIs) derived from standard automated perimetry (SAP) provides stronger structure-function correlations with ganglion cell layer thickness (GCLT) than conventional SAP in glaucoma. Methods: This cross-sectional study included 85 eyes of 55 glaucoma patients. All participants underwent SAP (Octopus 900) and MP-3 microperimetry (Nidek Co. Ltd). Individual high-density grids were customized to target the quadrant of lowest mean sensitivity on SAP. Optical coherence tomography (DRI-OCT Triton) was used to measure mean GCLT in the corresponding quadrant (GCLTq). Structure-function relationships between GCLTq and visual field (VF) sensitivity indices were analyzed with linear mixed-effects models accounting for inter-eye correlation. VF sensitivities were expressed on logarithmic and linear scales. Comparative model performance was assessed using Akaike's Information Criterion (AIC), ΔAIC, and Akaike weights (w Results: All VF indices correlated significantly with GCLTq (p < 0.05). MP-3 mean sensitivity on the linear scale (MS-MP3) showed the strongest association Conclusion: ROI-guided MP-3 microperimetry yielded a statistically supported yet modest improvement in structure-function correlation compared with SAP. The AIC-based analysis confirms that ROI targeting enhances the reliability and topographic accuracy of structure-function mapping in glaucoma.
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