Observational studyClinical interventions in aging2025
Evaluation of Potential Drug-Drug Interactions, Polypharmacy, and Prescribing Patterns of NSAIDs Among the Older Adults in a Secondary Care Setting.
Observational study in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Integrating Pharmacogenomics and Network Topology for Machine Learning Prediction of HLA-Associated Severe Cutaneous Adverse Drug Reactions.International journal of molecular sciences · 2026Article
- Pattern of use and awareness of side-effects of non-steroidal anti-inflammatory drugs among general public in Gondar city, North west Ethiopia.Scientific reports · 2026Article
- Acupotomy for Cervical Spondylosis-Related Neck Pain: A Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2026Article
- Potential Drug-Drug Interactions and Adverse Drug Reactions Among Elderly Psychiatric Outpatients Receiving Antipsychotics: A Cross-Sectional Study.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: In clinical practice, non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed to older adults patients for pain and inflammation. However, drug therapy in this population carries risks of polypharmacy and potential drug-drug interactions (pDDIs). This study aimed to evaluate prescribing trends of NSAIDs and examine the incidence of polypharmacy and pDDIs among older adults patients in the Outpatient Pharmacy Department of a secondary care hospital. Patients and Methods: A prospective observational study was conducted using electronic health records of older adults patients prescribed NSAIDs from January to June 2023. Data were screened for NSAID prescription patterns, polypharmacy, and pDDIs using the Micromedex database. Descriptive statistics and logistic regression assessed relationships between treatment-related factors and pDDIs, while Chi-square tested associations between NSAID prescriptions and gastro-protective drugs. A p-value <0.05 was considered statistically significant. Results: The study was conducted in 174 older adults patients. Celecoxib (28.2%) and ketoprofen (27.6%) were the most often given oral and topical NSAIDs among the study populations, respectively. Aspirin and celecoxib were the most commonly involved NSAIDs causing pDDIs. A total of 340 potential pDDIs were found, with a mean of 1.95 ± 3.66 interactions for each prescription. The analysis of polypharmacy in relation to treatment factors revealed a significant correlation with comorbidities (p < 0.001). A robust positive association exists between the quantity of pDDIs and continuous treatment-related factors, including the Charlson comorbidity index (p = 0.004), the comorbidity burden (p < 0.001), and the overall number of medications being taken (p < 0.001). Conclusion: The research elucidates the prescribing trends of NSAIDs and uncovers the occurrence of polypharmacy and pDDIs within the older adults population. Giving the right screening and intervention resources to maximize their medication regimen may ensure safer and more effective management of older adults patients.
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