ArticleFrontiers in endocrinology2025
Clinical characteristics and survival outcomes of extrapulmonary neuroendocrine carcinomas: a retrospective study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Clinicopathological characteristics and treatment outcomes of biliary neuroendocrine carcinoma: a single-center case series and literature review.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extrapulmonary neuroendocrine carcinomas (EPNECs) are rare, heterogeneous, and aggressive malignancies with limited evidence to guide management. This study aimed to investigate the clinical characteristics, prognostic factors, and treatment outcomes of EPNEC patients. Methods: We retrospectively analyzed 343 EPNEC patients treated at Harbin Medical University Cancer Hospital from May 2011 to December 2023. Data on demographics, primary tumor sites, tumor markers (CEA and NSE), treatments, and survival were collected. Kaplan-Meier and Cox proportional hazards models were used to evaluate prognostic factors, and subgroup analyses were performed for treatment modalities. Results: The median overall survival (OS) for the cohort was 23.7 months. Prognosis varied significantly by primary site, with genitourinary tumors showing the most favorable outcomes and hepatopancreatobiliary tumors the poorest. Independent predictors of worse survival included advanced stage (HR = 1.94, Conclusion: EPNEC prognosis is influenced by tumor site, stage, lymph node involvement, and biomarker levels. Surgery is optimal for early-stage disease (I/II), while chemotherapy and radiotherapy provide survival benefits in advanced-stage (III/IV) patients. Combined CEA and NSE elevation indicates a particularly poor prognosis. These findings highlight the importance of individualized, stage- and biomarker-driven therapeutic strategies for EPNECs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.