ArticleFrontiers in endocrinology2025
ACLY facilitates alanine flux in the livers of db/db mice: a hyperpolarized [1-13C]pyruvate MRS study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages.Journal of enzyme inhibition and medicinal chemistry · 2026Review
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4 authors.
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Abstract
Introduction: Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) feature paradoxical increases in both gluconeogenesis and lipogenesis. ATP citrate lyase (ACLY) supports both processes by generating cytosolic acetyl-CoA and oxaloacetate from citrate. While ACLY's role in lipogenesis is well established, its involvement in amino acid-driven gluconeogenesis remains unclear. Methods: Using hyperpolarized [1- Results: Hyperpolarized alanine labeling was markedly elevated in db/db livers, reflecting enhanced transamination capacity. Pharmacologic ACLY inhibition attenuated alanine- and glutamine-induced hyperglycemia and normalized alanine labeling within 2-4 h, without altering aminotransferase gene expression. These in vivo changes correlated with increased hepatic ACLY phosphorylation and ex vivo ALT assay results. Discussion: Together, these findings support a model in which ACLY facilitates amino acid-driven gluconeogenesis through metabolic control of ALT-mediated transamination, consistent with increased pyruvate-alanine exchange. Hyperpolarized [1-
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