Evidence map›Paper›PMID 41220568›Full record

ArticleFrontiers in cellular and infection microbiology2025

Natterin bridges IFN-φ1 and non-canonical inflammasome pathways via

Darlan Gusso, Felipe Justiniano Pinto, Aline Ingrid Andrade-Barros, Jefferson Thiago Gonçalves Bernardo, Carlos DeOcesano-Pereira, Monica Lopes-Ferreira, Carla Lima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Darlan GussoPlataforma Zebrafish of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute, São Paulo, Brazil.
Felipe Justiniano PintoPlataforma Zebrafish of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute, São Paulo, Brazil.
Aline Ingrid Andrade-BarrosPlataforma Zebrafish of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute, São Paulo, Brazil.
Jefferson Thiago Gonçalves BernardoPlataforma Zebrafish of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute, São Paulo, Brazil.
Carlos DeOcesano-PereiraCentre of Excellence in New Target Discovery (CENTD), Butantan Institute, São Paulo, Brazil.
Monica Lopes-FerreiraPlataforma Zebrafish of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute, São Paulo, Brazil.
Carla LimaPlataforma Zebrafish of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Natterin protein family represents an evolutionarily conserved group of immune effectors in teleosts, yet its broader regulatory role in host defense remains poorly understood. Here, we demonstrate that Natterin functions as a master upstream regulator, orchestrating a critical immune network that integrates type I interferon (IFN-I) signaling with non-canonical inflammasome activation during

Indexed as

Fish ProteinsInflammasomesInterferon Type IAnimalsGene Knockout TechniquesImmunity, InnateSalmonella Infections, AnimalSalmonella typhimuriumSignal TransductionFish ProteinsInflammasomesInterferon Type ICaspy2Gbp4/GSDMEhost defenseIFN-IinflammasomeNatterinsalmonella typhimuriumtranscriptional regulation

Identifiers

PMID41220568
PMCPMC12597722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.