Evidence map›Paper›PMID 41220443›Full record

ArticleCureus2025

Second-Trimester Uterine Rupture Following Misoprostol-Induced Termination in a Woman With a Previous Cesarean Section: A Case Report.

Ibrahim Kale, Mehtap Günes, Ipek Pehlivan, Melda Kuyucu

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ibrahim KaleObstetrics and Gynecology, Umraniye Training and Research Hospital, Istanbul, TUR.
Mehtap GünesObstetrics and Gynecology, Umraniye Training and Research Hospital, Istanbul, TUR.
Ipek PehlivanObstetrics and Gynecology, Umraniye Training and Research Hospital, Istanbul, TUR.
Melda KuyucuObstetrics and Gynecology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, TUR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Misoprostol, a prostaglandin E1 analogue, is widely used for medical termination of pregnancy due to its uterotonic properties. Although generally considered safe, uterine rupture is a rare but potentially life-threatening complication, particularly in women with a history of cesarean delivery. We report a case of a 23-year-old gravida 3, para 1 woman with one previous cesarean section who underwent second-trimester medical termination with the International Federation of Gynecology and Obstetrics (FIGO)-recommended misoprostol dosing. After the ninth dose, she developed sudden abdominal pain and syncope-like symptoms. Ultrasonography revealed uterine rupture with the fetus and placenta located in the abdominal cavity. Emergency laparotomy was performed, and the rupture along the previous cesarean scar was repaired. Her postoperative course was uneventful, and she was discharged on day 3. This case underscores the importance of early recognition of uterine rupture during misoprostol-induced second-trimester abortion and highlights the need for prompt surgical preparedness in women with prior uterine surgery.

Indexed as

medical termination of pregnancymisoprostolobstetric emergencysecond-trimester abortionuterine rupture

Identifiers

PMID41220443
PMCPMC12599851

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.