ArticleAnimal models and experimental medicine2025
Comprehensive study of Algerian nettles: Phenolic content and multifunctional activities of Urtica pilulifera and Urtica urens.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Comprehensive study of Algerian nettles: Phenolic content and multifunctional activities of Urtica pilulifera and Urtica urens.Animal models and experimental medicine · 2025Article
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9 authors.
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Abstract
backgroundThis study investigated the phenolic profile, antioxidant capacity, antibacterial effect, and antihemolytic activity of nettle leaves from two understudied Algerian species, Urtica pilulifera and Urtica urens.
methodsUrtica pilulifera and Urtica urens leaves extracts were prepared by maceration using methanol and distilled water respectively. Their phytochemical analysis (total phenolic content, flavonoids, hydrolysable and condensed tannins) was determined. The chemical profle of these extracts was performed using ultra-high-performance liquid chromatography diode array detection tandem mass spectrometry. Antioxidant activity (using the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging method), antibacterial activity (using disk diffusion method), and antihemolytic activity were carried out.
resultsResults reveal high levels of flavonoids, tannins, alkaloids, and terpenoids. Several classes of compounds were identified in the extracts. Phenolic acid and other acids and their derivatives and flavonoids were detected in the extracts, with 4-O-caffeoyl-quinic acid and 5-O-caffeoyl-quinic acid being the main constituents in both extracts. Caffeic acid was also the main constituent present only in U. urens extract. For antioxidant activity of the methanolic extract of U. pilulifera and the aqueous extract of U. urens, the percentage inhibition value (82.76% and 59.06%) and the half-maximum inhibitory concentration (IC
conclusionsThe study confirms the presence of bioactive substances in the nettle species, including flavonoids and tannins, which possess antioxidant, antibacterial, and antihemolytic properties, and can be processed into food and pharmaceutical products.
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