ArticleProteomics2025
Proteoform Mapping Calls for a Combined Effort From Bottom-Up and Top-Down Proteomics.
Article in Proteomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteomics has demonstrated that each protein consists of various proteoforms that provide an additional layer of biological data next to gene-, transcript-, or protein expression levels. As a result, proteome analyses are increasingly being complemented with proteoform maps. Identification and quantification of the type, site, and dynamics of a proteoform modification contribute to a better understanding of human biology. Testing the hypothesis that proteoform-resolved data can provide novel tools in precision medicine requires robust and high-throughput proteoform measurements. The prime candidate for this purpose is top-down proteomics (TDP), commonly performed with mass spectrometry. In this Special Issue: Top-Down Proteomics, Fornelli et al. report a comparative analysis of various SDS-removal methods that are needed for proteoform mapping in TDP experiments. Their work provides technical guidance on an important aspect of the TDP sample preparation process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.