Evidence map›Paper›PMID 41220249›Full record

ArticleAnnals of laboratory medicine2026

Reference Values for Extended Lymphocyte Subsets in Korean Children: A Multicenter Study Using the EuroFlow PIDOT Panel.

Kyung-Hwa Shin, Hyun-Woo Choi, Jihyang Lim, Eun-Suk Kang

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kyung-Hwa ShinDepartment of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0002-8454-4448
Hyun-Woo ChoiDepartment of Laboratory Medicine, Chonnam National University Hospital and Medical School, Gwangju, Korea.ORCID https://orcid.org/0000-0002-9438-1603
Jihyang LimDepartment of Laboratory Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-1459-8843
Eun-Suk KangDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6386-6520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Current reference intervals for lymphocyte subpopulations are primarily based on Western populations, with limited data available for Korean children, particularly for extended subsets. We determined absolute cell counts and percentages of lymphocyte subpopulations in Korean children, according to age and sex. Methods: Samples from 92 children-stratified into two age groups, groups 1 (5-9 yrs) and 2 (10-17 yrs)-were obtained. Immunophenotyping was performed via flow cytometry using the Primary Immunodeficiency Orientation Tube (PIDOT) panel, primarily classifying the cells into T, B, and natural killer cell populations. T lymphocytes were divided into CD4 Results: Children in group 1 exhibited higher absolute counts of total B cells, unswitched memory B cells/plasma cells, total T cells, CD4 Conclusions: To the best of our knowledge, this study is the first to establish reference values for extended lymphocyte subsets in Korean children using the PIDOT panel. Age, sex, and laboratory-related factors influenced lymphocyte subset distributions. These findings may serve as reference data for immune disorders and immunotherapy in pediatric populations.

Indexed as

Lymphocyte SubsetsAdolescentAsian PeopleB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChildChild, PreschoolFemaleFlow CytometryHumansImmunophenotypingInfantLymphocyte CountMaleReference ValuesB-lymphocyte subsetsLymphocyte subsetsNatural killer cellsT-lymphocyte subsets

Identifiers

PMID41220249
PMCPMC13071279

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