Evidence map›Paper›PMID 41220234›Full record

ArticleThe Veterinary record2025

Influence of ewe metabolic status on failure of passive transfer of immunity and lamb production in a UK lowland flock.

Rob F Kelly, Amy Jennings, Elizabeth Burrough, Geraldine Russell, Katie Adam, Emily Gascoigne, Peers L Davies, Jennifer S Duncan, Andy Hopker, Robert M Hyde and 3 more

Abstract read
In one paragraph

Article in The Veterinary record, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rob F KellyRoyal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.ORCID https://orcid.org/0000-0002-0946-1490
Amy JenningsRoyal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.ORCID https://orcid.org/0000-0001-7952-3119
Elizabeth BurroughRoyal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.
Geraldine RussellRoyal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.
Katie AdamRoyal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.
Emily GascoigneSynergy Farm Health, Dorchester, UK.ORCID https://orcid.org/0000-0001-5142-2690
Peers L DaviesDepartment of Livestock & One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Jennifer S DuncanDepartment of Livestock & One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0002-1370-3085
Andy HopkerRoyal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.ORCID https://orcid.org/0000-0002-5479-5430
Robert M HydeSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonnington, UK.
Fiona M LovattSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonnington, UK.ORCID https://orcid.org/0000-0003-2298-9174
Ann BruceSchool of Social and Political Science, University of Edinburgh, Edinburgh, UK.
Alexander CorbishleyRoyal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.

Funding

Agricultural and Horticultural Development BoardHyb Cig Cymru 61110070Quality Meat Scotland
6 · The paper itself

Abstract

backgroundInadequate ewe nutrition is an important driver for neonatal lamb losses, although the association of ewe metabolic status with lamb passive transfer status is poorly understood. This study investigates the relationship between ewe metabolic status, neonatal lamb losses, failure of passive transfer of immunity (FPTI) and lamb growth.

methodsEwes were blood sampled to assess metabolic status 3 weeks prior to the start of lambing. Within 8‒24 hours of birth, individual lamb weights, sex and litter size were recorded. Lambs were blood sampled to measure serum immunoglobulin G (IgG) to assess FPTI, and lamb outcomes were recorded until weaning.

resultsEwes had decreased odds of losing a lamb if they were scanned with twins and had a higher plasma albumin concentration. Lambs had an increased risk of FPTI (serum IgG < 24 mg/mL) if they were triplet lambs and if their mothers had increased plasma beta-hydroxybutyrate concentrations. Lambs with FPTI had increased odds of reduced growth (<0.26 kg/day). LIMITATIONS: This study was conducted in a single, well-managed, lowland flock. Therefore, the results may not be more widely generalisable.

conclusionsThis study highlights the potential association between ewe nutritional status, FPTI and lamb growth and indicates a need for a consensus IgG cut-off value for FPTI in lambs.

Indexed as

Immunity, Maternally-AcquiredAnimalsAnimals, NewbornFemaleImmunoglobulin GMaleNutritional StatusPregnancySheepUnited KingdomImmunoglobulin G

Identifiers

PMID41220234
PMCPMC12699954

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.