ArticleJournal of the American Heart Association2025
Childhood Neurocognitive Outcomes in Patients With Fontan Circulation.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo assess childhood neurocognitive outcomes in a contemporary Fontan cohort and to identify neurodevelopmental risk factors.
methodsThis retrospective cohort study enrolled patients with a single ventricle born between 2004 and 2019 receiving standardized neurocognitive testing with age-appropriate Wechsler intelligence scales after staged univentricular palliation. Demographic, surgical, and perioperative data were collected to evaluate neurodevelopmental risk factors.
resultsData from 204 patients assessed at 5.0 (interquartile range, 4.5-6.1) years of age were analyzed. Full-scale IQ (FSIQ) was in the lower normal range (93.5±12.3) but below population norms (
conclusionsIn this contemporary Fontan cohort, mean FSIQ was in the low normal range but with a higher proportion of patients with intellectual impairment. Hypoplastic left heart syndrome or use of cardiopulmonary bypass for neonatal palliation was not associated with lower FSIQ scores. Preoperative condition and patient-related factors were more important determinants of cognitive function than variables related to surgical palliation.
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