ArticleJournal of the American Heart Association2025
Development of a Novel Murine Model of In-Stent Neoatherosclerosis.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- Salvianolic Acid a Disrupts the HSP90α-AKT-PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Towards Neoatherosclerosis: A Porcine Model for Enhanced Device Testing.Journal of cardiovascular translational research · 2026Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn-stent neoatherosclerosis is a complication of percutaneous coronary intervention with stenting. Although similar to de novo atherosclerosis, it develops rapidly within 1 to 5 years rather than over a lifetime. No preclinical small animal model exists to fully elucidate neoatherosclerosis biology or evaluate targeted therapies. This study aimed to establish and validate a novel murine model of in-stent neoatherosclerosis.
methodsMurine stainless-steel stents (2.5×0.7 mm) were deployed into donor descending aortas of atherosclerosis-prone
resultsBimodal intravascular imaging combined optical coherence tomography (plaque burden) with fluorescence detection of indocyanine green (plaque instability) to visualize in-stent neoatherosclerosis along the entire stented segment. Histological analyses revealed that stented vessels from mice fed high-cholesterol diet had neointimas with prominent lipid cores and abundant CD68
conclusionsWe have developed and validated the first murine model that replicates the unique characteristics of human in-stent neoatherosclerosis. This has implications for exploring the mechanisms that promote neoatherosclerosis and testing targeted new therapies.
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