Evidence map›Paper›PMID 41220133›Full record

ArticleJournal of the American Heart Association2025

Noninvasive Myocardial Work Predicts Long-Term Postinterventional Outcomes in Patients With Primary Mitral Regurgitation.

Yun Yang, Lingyun Fang, Yuji Xie, Wenqian Wu, He Li, Lin He, Huan Wang, Tezhi Alimu, Xin Zhang, Tan Liu and 9 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yun YangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0001-6467-2656
Lingyun FangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0003-3789-3001
Yuji XieDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0002-5755-4819
Wenqian WuDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0002-0452-9273
He LiDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Lin HeDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0002-9128-6029
Huan WangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Tezhi AlimuDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0009-0002-1858-6639
Xin ZhangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0001-5468-6210
Tan LiuDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0001-8847-0258
Jiatong LiDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Ruize ZhangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Linyue ZhangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0009-0008-0937-3184
Yuting TanDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0003-3830-5013
Shukun HeDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Yuman LiDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0002-4388-8199
Li ZhangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0003-1620-1512
Jing WangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0002-3773-1005
Mingxing XieDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID 0000-0003-4984-1567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate and early identification of impaired left ventricular (LV) function is essential to the optimal timing of intervention for primary mitral regurgitation. Myocardial work derived from noninvasive pressure-strain loop is a novel and promising afterload-independent approach to evaluate LV performance. We hypothesized that it may provide diagnostic and prognostic utility in these patients. This study aimed to evaluate myocardial work parameters in patients with significant primary mitral regurgitation, and explore their association with postinterventional LV ejection fraction and clinical composite events.

methodsThe study prospectively enrolled 180 patients with severe primary mitral regurgitation at baseline and patients were followed up for postinterventional LV function (>12 months) and clinical events (24.0 [23.3-24.6] months). Logistic regression and Cox proportional hazards regression analyses were performed as appropriate.

resultsCompared with patients exhibiting postinterventional LV ejection fraction ≥50%, individuals with LV ejection fraction <50% demonstrated lower LV global longitudinal strain, global work index (GWI), global constructive work (GCW), and global work efficiency (

conclusionsMyocardial work parameters, especially GWI, GCW, and global work efficiency, are independent predictors of postinterventional LV dysfunction and are associated with the occurrence of postinterventional clinical composite events.

Indexed as

Mitral Valve InsufficiencyMyocardial ContractionStroke VolumeVentricular Dysfunction, LeftVentricular Function, LeftAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesSeverity of Illness IndexTime Factorsechocardiographymitral valve regurgitationmyocardial workprognostic value

Identifiers

PMID41220133
PMCPMC12887227

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.