ArticleJournal of orthopaedic surgery and research2025
Platelet-rich plasma enhanced therapy for aseptic atrophic tibial diaphyseal nonunion: a single-center retrospective controlled study of 90 cases.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Orthobiologics in Trauma: Current Trends, Future Directions, and Regenerative Strategies.Cureus · 2026Review
- Induced membrane-mediated DBM in combination with PRP: an autologous bone graft substitute therapy with remarkable osteoformation potency for challenging bone defects.International journal of surgery (London, England) · 2026Article
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7 authors.
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Abstract
backgroundAlthough successful outcomes of platelet-rich plasma (PRP) in treating nonunion fractures have been reported, there are widespread confounding factors and biases in the studies. This study aims to assess the biological benefits of PRP-enhanced therapy while controlling for the two core factors of nonunion fractures-biomechanics and biology.
methodsRetrospective analysis of medical records of patients with aseptic atrophic tibial diaphyseal fracture nonunion treated with a single locking plate in a tertiary trauma center. Patients were divided into the PRP group and the non-PRP group based on the use of PRP. The surgical procedure for the non-PRP group was a single locked plate fixation combined with autologous iliac bone grafting. For the PRP group, PRP-enhanced autologous iliac bone grafting and the creation of a bioactive chamber were added. The outcome measures included the union rate, average healing time, visual analog scale pain score, lower limb function score, and complications.
resultsA total of 90 patients were included, with 39 patients in the PRP group and 51 patients in the non-PRP group. The average follow-up was 16.15 ± 3.14 months in the PRP group and 15.86 ± 3.26 months in the non-PRP group. No significant differences were observed between the two groups in terms of demographic characteristics and disease parameters (P > 0.05). At 9 months post-revision surgery, the healing rate in the PRP group was higher than that in the non-PRP group (58.97% vs 33.33%, p = 0.015,χ
conclusionIn the treatment of atrophic fracture nonunion, PRP enhanced autologous iliac bone grafting can shorten bone healing time and accelerate the healing process, thereby improving limb function more rapidly. This finding provides a superior treatment option clinically for patients in need of accelerated nonunion healing and early recovery of lower limb function.
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