ArticleJournal of medical case reports2025
Unveiling the mandibular mystery: a case of central giant cell granuloma in posterior mandibular region-a case report.
Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPreviously called giant cell reparative granuloma, central giant cell granuloma is an intraosseous lesion of unclear cause that is benign but may become aggressive. It frequently crosses the midline and typically affects the anterior area of the jaw, particularly in young females. Because the posterior mandibular lesion is uncommon, especially in middle-aged people, these presentations are difficult to diagnose and have clinical significance. CASE PRESENTATION: A 37-year-old Indian female reported that she had been experiencing a painful, progressively growing bulge in her left posterior jaw for the previous 4 months. It was accompanied by paresthesia of lower left side of the face. Upon intraoral examination, a firm, nontender enlargement that stretched from the premolar to the molar region was discovered. A reactive bone lesion was suggested by a multilocular radiolucency found during radiographic assessment. Central giant cell granuloma was diagnosed after an incisional sample and histological examination. The patient had the affected side segmentally resected owing to the size and placement of the lesion. There was no recurrence observed during the follow-up period, and the postoperative recovery went smoothly.
conclusionIn contrast to the usual demographic and anatomical trends, this case illustrates a rare presentation of central giant cell granuloma in the posterior mandible of a middle-aged female. The significance of taking central giant cell granuloma into account when making a differential diagnosis for jaw swellings other than anterior region and in older age groups is highlighted by this atypical placement. By describing an uncommon site of involvement, the case contributes significantly to the limited literature on this atypical presentation. It also emphasizes the necessity of thorough clinical, radiographic, and histological correlation for precise diagnosis and treatment.
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