SynthesisBiomedical engineering online2025
The clinical efficacy and impact on fertility function of laparoscopic surgery versus methotrexate for treatment of tubal pregnancy: a meta-analysis.
Synthesis in Biomedical engineering online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo systematically review and compare the clinical efficacy and impact on fertility function between laparoscopic surgery and methotrexate treatment for tubal pregnancy.
methodsFive English databases and four Chinese databases were systematically searched from the database establishment to January 31, 2024, and a meta-analysis was conducted using Review Manager 5.3.
resultsTen articles were included, with a total of 1,034 study patients. The meta-analysis showed that compared with a single intramuscular injection of methotrexate, laparoscopic surgery for tubal pregnancy was associated with a significantly higher tubal patency rate [OR = 2.47, 95% CI 1.72-3.53, P < 0.001]; and a significantly higher spontaneous pregnancy rate [OR = 2.10, 95% CI 1.28-3.46, P = 0.003]; and a shorter time for serum HCG levels to return to normal [MD = -7.10, 95% CI - 7.84-6.36, P < 0.001]. However, there was no statistically significant difference in treatment success rate between the two treatment methods [OR = 1.88, 95% CI 0.53-6.69, P = 0.33], and no statistically significant difference in recurrent EP rate [OR = 1.09, 95% CI 0.41-2.87, P = 0.87].
conclusionCompared with a single intramuscular injection of methotrexate, laparoscopic surgery for tubal pregnancy is associated with better fertility function in the future, while the difference in clinical efficacy needs further exploration.
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