ReviewCell communication and signaling : CCS2025
Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer.
Review in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Distinct responses ofMolecular therapy. Nucleic acids · 2026Article
- Molecular Characterization ofCancers · 2026Article
- Nonsense-mediated mRNA decay and associated splicing patterns in neurodevelopmental disorders.Frontiers in molecular biosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately linked to tumorigenesis. When NMD becomes overactivated, it can downregulate tumor suppressor transcripts, or eliminate immunogenic peptides, thereby promoting tumor growth and immune evasion. In contrast, reduced or defective NMD can stabilize mutated oncogene transcripts and drive tumor progression. This review provides a comprehensive overview of the physiological mechanisms of NMD, its diverse substrate features, and its regulatory dynamics. We further focus on recent advances in clarifying the interplay between NMD and tumor biology. By integrating the current findings, we aim to provide an insightful understanding of how NMD contributes to tumor initiation, tumor progression, and immune modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.