Evidence map›Paper›PMID 41219886›Full record

ArticleBMC geriatrics2025

Bidirectional relationships between disability and cognitive decline: a 6-year longitudinal study.

Tsung-Hsuan Hung, Tzu-Yun Wang, Hung-Chang Chou, Ching-Ju Chiu, Chia-Ning Lee, Huai-Hsuan Tseng, Kao Chin Chen, Yan-Jhu Su, Andrew Alberth, Yen Kuang Yang and 1 more

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Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Tsung-Hsuan HungDepartment of Medical Education, Kaohsiung Chang Gung Memorial Hospital, No.123, Dapi Rd, Niaosong District, Kaohsiung, 833, Taiwan.
Tzu-Yun WangDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd, North District, Tainan City, 70428, Taiwan.
Hung-Chang ChouDepartment of Pharmacy and Master Program, Tajen University, No.20, Weixin Rd, Yanpu Township, Pingtung, 907, Taiwan.
Ching-Ju ChiuInstitute of Gerontology, College of Medicine, National Cheng Kung University, No.1, University Rd, North District, Tainan City, 701, Taiwan.
Chia-Ning LeeDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd, North District, Tainan City, 70428, Taiwan.
Huai-Hsuan TsengDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd, North District, Tainan City, 70428, Taiwan.
Kao Chin ChenDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd, North District, Tainan City, 70428, Taiwan.
Yan-Jhu SuDepartment of Gerontology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, 02125, USA.
Andrew AlberthDepartment of Gerontology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA, 02125, USA.
Yen Kuang YangDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd, North District, Tainan City, 70428, Taiwan.
Tsung-Yu TsaiDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd, North District, Tainan City, 70428, Taiwan. zxoctry16@hotmail.com.

Funding

National Cheng Kung University Hospital NCKUH-11204032
6 · The paper itself

Abstract

backgroundDisability and cognitive impairment are two significant age-related health issues in older adults. This study aims to simultaneously identify the bidirectional relationship between disability and cognitive impairment, and further pinpoint which one holds a more pivotal role in the relationship.

methodsA total of 628 participants aged 66.0 (SD = 7.3) were retrieved from the 2000 and 2006 Social Environment and Biomarkers of Aging Study (SEBAS). Cognitive function was assessed using the modified Short Portable Mental Status Questionnaire (SPMSQ). Disability was measured as a count of activity of daily living, instrumental activity of daily living, and mobility scales. Structural equation models with cross-lagged analysis were used to examine the temporal relationship between cognitive impairment and disability over six years.

resultsThe cross-lagged model was well constructed (χ2 (9) = 34.5941, p < 0.0001, RMSEA = 0.0673, CFI = 0.99, SRMR = 0.03). Baseline disability significantly predicted future cognitive impairment (β=-0.25, p < 0.05), and baseline cognition significantly predicted future disability (β=-0.03, p < 0.05). Fisher's Z test indicated a stronger pathway from disability to future cognitive impairment compared to cognitive impairment to future disability (p < 0.001).

conclusionThis longitudinal study suggested that disability and cognition change were bidirectional, with disability showing a stronger impact on future cognitive impairment. Further dynamic investigations and mechanisms between cognitive change and disability are warranted.

Indexed as

Activities of Daily LivingAgingCognitive DysfunctionDisability EvaluationPersons with DisabilitiesAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMiddle AgedBidirectional relationshipsCognitive changeDisabilityOlder adults

Identifiers

PMID41219886
PMCPMC12606942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.