Evidence map›Paper›PMID 41219858›Full record

ArticleBMC gastroenterology2025

Concordance of cancer-associated cytokines and mitochondrial DNA deletions in individuals with hepatocellular carcinoma and people living with HIV in Ghana.

James Odame Aboagye, Ruth Ayanful-Torgby, Lei Zhou, Prince Peter Wormenor, Vincent Ganu, Kenneth Tachi, Bernard Nii Akrashie Attoh, Miriam Mensah, Timothy Kuuguu, Sedzro Kojo Mensah and 2 more

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In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

James Odame AboagyeDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Ruth Ayanful-TorgbyDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Lei ZhouDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Prince Peter WormenorDepartment of Virology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
Vincent GanuDepartment of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana.
Kenneth TachiDepartment of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana.
Bernard Nii Akrashie AttohMedical and Scientific Research Centre, University of Ghana Medical Centre, Legon, Accra, Ghana.
Miriam MensahDepartment of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana.
Timothy KuuguuDepartment of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana.
Sedzro Kojo MensahDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
George Boateng KyeiDepartment of Virology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
Elijah PaintsilDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA. elijah.paintsil@yale.edu.

Funding

Training and Research on Arboviruses and Zoonoses In Nigeria and Sierra Leone (TRAIN)D43TW012246 · FIC · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Nikos Vasilakis, Scott C Weaver · 2022 to 2026
$1.2M
FIC NIH HHS D43 TW012246
6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is becoming increasingly prevalent as a non-AIDS-defining cancer closely tied to chronic HIV infection. It is associated with increased secretion of inflammatory cytokines, immune system dysfunction, and alterations in mitochondrial function. The objective of this study was to investigate the levels of cytokine secretion and mitochondrial DNA (mtDNA) deletion in people living with HIV (PLWH) compared with individuals diagnosed with HCC without HIV.

methodsA cross-sectional study was conducted with PLWH and HCC patients recruited from the Korle-Bu Teaching Hospital, Accra, Ghana. Participants donated whole blood for the isolation of plasma and peripheral blood mononuclear cells (PBMCs) for analysis. Cytokines were quantified in plasma samples using ELISA and Luminex techniques, while mtDNA deletions were determined with DNA extracted from the PBMCs.

resultsThe study found that the secretion of the cytokines TGF-β, FGF2, IL-8, TNF-α, VEGFA, and RANTES was similar in patients with HCC and PLWH. These cytokines have been implicated in HCC initiation and are also elevated in the early stages of the disease. Moreover, we observed comparably high levels of mtDNA deletion in PLWH and HCC patients.

conclusionsThese findings underscore the risks associated with HCC development in PLWH. There is a need for screening among PLWH, and these differentially expressed cytokines could serve as potential biomarkers.

Indexed as

Carcinoma, HepatocellularCytokinesDNA, MitochondrialHIV InfectionsLiver NeoplasmsAdultAgedCross-Sectional StudiesFemaleGhanaHumansLeukocytes, MononuclearMaleMiddle AgedSequence DeletionCytokinesDNA, MitochondrialHepatitisHepatocellular carcinoma (HCC)Human immunodeficiency virus (HIV)Inflammatory cytokinesMitochondrial DNA deletion

Identifiers

PMID41219858
PMCPMC12606890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.