ArticleBMC cancer2025
Rapidly increasing kidney cancer burden among young adults: insights from the 1990-2021 Global Burden of Disease Study.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundKidney cancer (KC) is a major global health concern. Considering the significant impact of premature morbidity and mortality in young adults on the global disease burden, it is essential to conduct a longitudinal study on KC in young adults to develop cost-effective interventions.
methodsAge-standardized rates (ASRs) including incidence rate (ASIR), mortality rate (ASMR), and disability-adjusted life-years (DALYs) rate (ASDR), and ASDR attributable to risk factors (obesity, smoking, exposure to trichloroethylene, etc.) of KC were analyzed using Global Burden of Disease Study 2021 data (1990-2021), in the whole population and among young adults aged 20-39 years by sex, age, and socio-demographic index (SDI). Mortality to incidence ratio (MIR), percentage change, estimated annual percentage change (EAPC) and the correlation between ASR and SDI were evaluated. Future forecasts of KC burden until 2050 were performed.
resultsASIR among young adults aged 20-39 years increased (EAPC = 1.13%, P < 0.001), ranking second only to those over 80 years old. ASMR declined, with the slowest decrease observed among those aged 20-39 years (EAPC = -0.12%; P = 0.003), mainly due to the upward trend observed among males (EAPC = 0.11%, P = 0.022). No change of ASDR was detected among young adults despite of decreasing trend in the whole population. ASDR attributable to high BMI exhibited an overall increasing trend, particularly among young adults (EAPC = 1.28%, P < 0.001), whereas that attributable to smoking decreased most significantly (EAPC = -1.96%, P < 0.001). High SDI countries contributed the most to this declined trend, however they possess the highest baseline ASRs. ASMR and ASDR continued to rise in middle and low-middle SDI countries. By 2050 young male adults show a significant upward trajectory in KC burden, while the declining trends were observed in the whole population.
conclusionsThis study highlights the urgent need to address the increasing KC burden among young adults, particularly males, as well as in high, middle, and low-middle SDI countries.
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