Observational studyBMC infectious diseases2025
Analysis and comparison of chickenpox outbreaks in two schools at different educational stages: a mixed retrospective observational study.
Observational study in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Effectiveness of varicella vaccine during a varicella outbreak in a Chinese senior high school: a retrospective cohort study.Frontiers in immunology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundVaricella (commonly known as chickenpox) poses a major public health challenge in China, frequently triggering public health emergencies within schools. Distinct age demographics and vaccination rates drive divergent epidemic patterns in primary versus high schools, necessitating comparative analysis of outbreak characteristics and interventions to optimize targeted prevention strategies.
methodsA mixed retrospective observational study was conducted to systematically assess varicella outbreaks across two Shenzhen schools, quantifying key epidemiological parameters including outbreak duration and serial intervals. We employed a multidimensional analytical framework to characterize intergenerational transmission patterns and compare epidemic progression between distinct educational stages. Intervention effectiveness was rigorously evaluated through stratified analyses of gender-specific attack rates and vaccine-conferred immunity.
resultsThe proportion of cases presenting with a rash as the initial symptom in primary school students (60.41%) was significantly higher compared to high school students (34.78%) (χ
conclusionThe characteristics of individuals affected by varicella outbreaks varied across different stages of education. Analyzing intergenerational epidemic data can enhance our understanding of the pattern of epidemic transmission. Vaccine history in older children exhibited a relatively limited impact on morbidity rates. Beyond emergency vaccination campaigns, complementary containment strategies should be implemented to mitigate school-based varicella outbreaks. CLINICAL TRIAL NUMBER: Not applicable.
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