ReviewThe journal of headache and pain2025
Decoding orofacial pain: a translational review of mechanisms and novel therapies.
Review in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Neural Mechanisms and Brain Alterations in Orofacial Pain: A Narrative Review of Human Neuroimaging.Diagnostics (Basel, Switzerland) · 2026Review
- Symptom Persistence Across Selected Orofacial Conditions: Toward a Chronic Explanatory Profile.Journal of oral rehabilitation · 2026Review
- The Pathophysiological Mechanisms of Glia in Animal Models of Chronic Orofacial Pain: A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Development and validation of a clinical prediction model for acupuncture response in community-dwelling patients with chronic low back pain: a retrospective cohort study.BMC health services research · 2026Article
- A glutamatergic ventrolateral periaqueductal gray-lateral habenula pathway is associated with depression-like behavioral measures in young adult male mice with trigeminal neuropathic pain.The journal of headache and pain · 2026Article
- Diagnostic re-evaluation of non-odontogenic orofacial pain after treatment failure: a retrospective case series.Journal of oral & facial pain and headache · 2026Article
- Review
- Post-stroke headache: a review of epidemiology, pathophysiology, and clinical management.Frontiers in neuroscience · 2026Review
- Orbital Metastases of Breast Cancer: Case Report and Review of the Literature.Oncology research · 2026Review
- Editorial: Oro-facial pain: pathophysiology, molecular mechanisms, diagnostic innovations and multidisciplinary management.Frontiers in oral health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Orofacial pain encompasses a diverse group of disorders that pose a significant clinical challenge, often progressing from acute to chronic conditions due to a disconnect between clinical diagnosis and underlying pathophysiology. This review provides a synthesis of the mechanisms driving this transition and evaluates emerging therapeutic strategies that target them. First, we dissect the pathophysiological mechanisms of acute pain, including peripheral sensitization and transient central sensitization; and then detail how these processes can become maladaptive, leading to chronic pain states sustained by a combination of persistent nociceptive input, neuropathic alterations, and nociplastic changes involving dysfunctional descending modulation and central network reorganization. Building on this mechanistic framework, we critically appraise novel therapeutic approaches, including targeted pharmacotherapies such as selective ion channel and endocannabinoid system modulators, alongside non-pharmacotherapeutic interventions that encompass neuromodulation techniques designed to regulate central neural plasticity and psychologically grounded therapies. By integrating molecular evidence with clinical presentations, this review offers a framework for advancing towards a more precise, mechanism-based management of orofacial pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.