Observational studyBMC cardiovascular disorders2025
Sex-Specific heart rate acceleration as predictors of positive head-up tilt test outcomes in syncope patients.
Observational study in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06496074 (Sex-Specific Heart Rate Variations in Predicting Outcomes of Head-Up Tilt Tests in Syncope Patients), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Sex-Specific Heart Rate Variations in Predicting Outcomes of Head-Up Tilt Tests in Syncope Patients
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHead-up tilt test (HUTT) is widely used to evaluate patients with unexplained syncope, but data on clinical predictors of HUTT results are limited. This study aimed to evaluate heart rate (HR) acceleration and blood pressure (BP) changes associated with the HUTT results in syncope patients and the differences according to sex.
methodsA cross-sectional study was performed with patients who presented with unexplained syncope and were subjected to HUTT (70-degree angle) from January 2011 to April 2015. BP changes and Receiver Operating Characteristic (ROC) curves for the maximum interval in HR acceleration from the first to the tenth minute (delta-HR 10) after tilting were analyzed. The significance level was set at 5%.
resultsOf 149 patients (mean age: 28.5 ± 29 years), 40 (26.85%) had a positive HUTT. The delta-HR 10 acceleration was higher in the positive group (14.0 ± 9.25 bpm vs. 9.0 ± 11 bpm, p = 0.002). When considering sex, a cut-off point of 12 bpm was found, with an area under the curve of 0.805 for females, showing a sensitivity of 80% and a negative predictive value of 91.2%, and an area under the curve of 0.580 for males, with a sensitivity of 52% and a negative predictive value of 73.9%.
conclusionsThe HR acceleration of 12 bpm up to the tenth minute after tilting was an independent predictor of a positive HUTT in female syncope patients, demonstrating good sensitivity, accuracy, and negative predictive value.
trial registrationClinicalTrials.gov Identifier: NCT06496074.
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