ReviewEuropean journal of medical research2025
A novel approach to the prevention and management of cardiovascular diseases: targeting brain-heart axis.
Review in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Effects of Empagliflozin Combined with Anaerobic, Aerobic, and Endurance Swimming Protocols on Cardiac Structure and Electrophysiology in Healthy Rats.Journal of clinical medicine · 2026Article
- Adenosine Signaling as a Central Integrative Network in Cellular Stress Responses and a Therapeutically Actionable Target in Human Disease.Biomolecules · 2026Review
- Concomitant Dysregulation of Cerebral Vasoreactivity and Arterial Blood Pressure Is Closely Related in Patients with Carotid Stenosis.Life (Basel, Switzerland) · 2026Article
- Ventricular cardiac magnetic resonance traits and schizophrenia risk: a UK Biobank and Mendelian randomization study.Frontiers in psychiatry · 2026Article
- Loneliness and cognitive aging: a brain-heart axis perspective on a modifiable risk.Frontiers in aging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Epidemiological studies indicate that cardiovascular diseases are the leading cause of death and disability worldwide, imposing a significant socioeconomic burden. Despite continuous medical advancements and new preventive measures offering new prospects for the treatment of cardiovascular diseases, the incidence and mortality rates remain high, presenting a challenging outlook for prevention and treatment. Exploring new strategies for preventing and treating cardiovascular diseases has become particularly urgent. The recent research has shown a close relationship between heart health and brain health. The autonomic neural central network in the brain regulates heart function through efferent activities. Cardiac dysfunction leads to afferent remodeling of the heart, adversely affecting central neural circuits and impairing higher brain functions, hence giving rise to the "brain-heart axis" concept. In the recent years, the concept of the brain-heart axis has been further refined into the brain-heart axis and heart-brain axis. The brain-heart axis has become a new target for preventing and treating cardiovascular diseases. Establishing a comprehensive theoretical and mechanistic framework of the brain-heart axis is essential for enhancing our systematic understanding of the pathophysiological mechanisms of cardiovascular diseases and finding new therapeutic approaches. We will explore brain-heart interactions, including ischemic stroke-induced, stress-induced, and neurodegenerative cardiac damage, and discuss the potential mechanisms behind these interactions. In addition, we will summarize research on targeted brain function activity detection and cardiovascular disease prevention, aiming to provide references for future in-depth research and precision treatment in targeting brain regions for cardiovascular disease prevention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.