ArticleEpigenetics & chromatin2025
Dna methylation dynamics associated with visual system remodeling during flatfish metamorphosis.
Article in Epigenetics & chromatin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFlatfish metamorphosis involves dramatic tissue remodeling, including the migration of one eye to the opposite side of the body, enabling the transition from pelagic to benthic life. While this process requires precise transcriptional regulation, the role of epigenetic mechanisms remains poorly understood. Here, we investigate DNA methylation dynamics during turbot metamorphosis using reduced-representation bisulfite sequencing (RRBS) across three key stages: pre-metamorphosis, climax, and post-metamorphosis.
resultsWe identified stage-specific methylation patterns, with more than 31% of hypermethylated regions emerging during the climax phase-coinciding with upregulated dnmt3a (de novo methyltransferase) and altered expression of photoreceptor adaptation genes. Critically, the migrating and non-migrating eyes exhibited divergent methylation and expression of retinal ganglion cell (RGC) regulators (eomesa, tbr1b), linking epigenetic changes to asymmetric ocular development.
conclusionOur results suggest that DNA methylation may play a role in visual system remodeling, particularly in processes associated with RGC-mediated eye migration and light-sensing adaptation, providing new understanding of the epigenetic regulation of vertebrate metamorphosis.
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