Evidence map›Paper›PMID 41219813›Full record

SynthesisEuropean journal of medical research2025

The effects of progesterone supplementation in pregnancies assessed by doppler ultrasound: a systematic review of maternal and perinatal outcomes.

Somayeh Khanjani, Sheida Bashiri Goodarzi, Mohammad Mehdi Khaleghi, Seyyede Sepide Ashraf Moosavi, Reza Eshraghi, MohammadSaeed Soleimani Meigoli, Mobina Fathi, Maryam Nasr Azadani, Nazanin Sadraei, Ashkan Bahrami

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Somayeh KhanjaniAssistant Professor of Obstetrics and Gynecology, Perinatologist, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0002-2911-2001
Sheida Bashiri GoodarziSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Mehdi KhaleghiDepartment of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.ORCID http://orcid.org/0000-0002-7026-9019
Seyyede Sepide Ashraf MoosaviStudent Research Committee, Kashan University of Medical Sciences, Kashan, Iran.ORCID http://orcid.org/0009-0009-2225-5710
Reza EshraghiSocial Determinants of Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0003-3435-3851
MohammadSaeed Soleimani MeigoliNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.ORCID http://orcid.org/0009-0006-6033-8515
Mobina FathiStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-4811-3982
Maryam Nasr AzadaniStudent Research Committee, Kashan University of Medical Sciences, Kashan, Iran.ORCID http://orcid.org/0009-0005-9249-9033
Nazanin SadraeiMedical Imaging Research Center, Shiraz University of Medical Sciences, Zand Blvd, Shiraz, 7193613311, Iran. na.sadraei@gmail.com.ORCID http://orcid.org/0000-0003-4024-7916
Ashkan BahramiInterventional Cardiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Science (MUI), Shahid Rahmani Alley, Moshtagh Sevom St., Isfahan, 8158388994, Iran. ashkanbahrami1998@gmail.com.ORCID http://orcid.org/0000-0003-2158-2567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProgesterone is essential for pregnancy maintenance, but its effects on complications like intrauterine growth restriction (IUGR), preeclampsia, prelabor rupture of membranes (PROM), preterm birth, and placental abruption are still debated. This review investigates the effects of progesterone supplementation on Doppler ultrasound indices and pregnancy outcomes. MATERIAL AND

methodsTo assess the efficacy of progesterone supplements in reducing pregnancy complications during the first and second trimesters using Doppler ultrasound indices. Databases such as PubMed, Embase, the Cochrane Library, MEDLINE, Web of Science, Scopus, and Google Scholar were searched from inception to March 2024. Cohort, case-control, and clinical trials on progesterone supplementation in early to mid-pregnancy were included in the review. The primary outcomes were Doppler ultrasound indices, with secondary outcomes including preterm birth, IUGR, preeclampsia, PROM, and placental abruption. Nine studies with 2282 women were examined. Independent reviewers extracted data and assessed its quality, resolving discrepancies through consensus.

resultsProgesterone supplementation had varying effects on Doppler indices. There was no significant difference in uterine or umbilical artery Doppler indices, but some studies reported changes in fetal middle cerebral artery flow. Furthermore, there were no significant improvements in the rates of IUGR, preeclampsia, or PROM.

conclusionsProgesterone supplementation in early and mid-pregnancy may benefit certain subgroups, particularly those at risk of preterm birth. However, its overall effectiveness in improving clinical outcomes is unclear. More research using standardized progesterone regimens is needed to better understand its role in pregnancy management. Progesterone supplementation may help prevent preterm birth in high-risk populations, such as women with a short cervix. However, Doppler ultrasound findings should not be the sole factor in guiding its use. However, its role in improving other clinical outcomes, such as IUGR and preeclampsia, remains uncertain. Obstetricians should consider progesterone use as part of individualized treatment plans, particularly for women at high risk for preterm birth.

Indexed as

Pregnancy ComplicationsProgesteroneUltrasonography, DopplerDietary SupplementsFemaleFetal Growth RetardationHumansPre-EclampsiaPregnancyPregnancy OutcomePremature BirthUltrasonography, PrenatalProgesteroneDoppler ultrasoundIntrauterine growth restrictionPreeclampsiaPremature rupture of membranesPreterm birthProgesterone

Identifiers

PMID41219813
PMCPMC12606974

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.