ArticleJournal of ovarian research2025
Risk factors and clinical outcomes of late-onset severe ovarian hyperstimulation syndrome in advanced maternal age women undergoing fresh embryo transfer.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSince young age is an established risk factor for ovarian hyperstimulation syndrome (OHSS), most research has consequently focused on early-onset OHSS in this patient population. With increasing fertility demands among advanced maternal age (AMA) populations, their reproductive health and assisted reproductive outcomes have garnered significant clinical attention. However, there are few reports on late-onset OHSS in AMA patients, and its risk factors and impact on pregnancy outcomes remain unknown.
methodsThis retrospective study analyzed 13,040 fresh embryo transfer cycles with positive serum hCG results in women aged ≥ 35 years from January 2010 to December 2021. Patients were stratified based on the occurrence of late-onset severe OHSS. Pregnancy and neonatal outcomes were analyzed and multivariable regression analysis was used to identify risk factors of OHSS in advanced-age women.
resultsWithin this cohort, 142 patients were diagnosed with late-onset severe OHSS. Both long and ultra-long COH protocols were associated with a significantly higher risk of OHSS compared to the antagonist protocol. Lower total Gn dosage, higher trigger-day E
conclusionElevated trigger-day E2 levels and increased good-quality embryos independently predict late-onset severe OHSS risk in AMA women, without compromising pregnancy outcomes.
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