Evidence map›Paper›PMID 41219739›Full record

ArticleJournal of nanobiotechnology2025

Advanced nitric oxide-activated calcium overload and zinc ion-amplified oxidative imbalance in ferroptosis/apoptosis.

Hongmei Zhou, Yujia Liang, Lijuan Liu, Yulin Liang, Jiaying Tang, He Ding, Shufang Ning, Piaoping Yang, Chen Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongmei ZhouDepartment of Experimental Research, University Engineering Research Center of Oncolytic & Nanosystem Development (Guangxi), Guangxi Medical University Cancer Hospital, Nanning, 530021, P. R. China.
Yujia LiangDepartment of Experimental Research, University Engineering Research Center of Oncolytic & Nanosystem Development (Guangxi), Guangxi Medical University Cancer Hospital, Nanning, 530021, P. R. China.
Lijuan LiuDepartment of Experimental Research, University Engineering Research Center of Oncolytic & Nanosystem Development (Guangxi), Guangxi Medical University Cancer Hospital, Nanning, 530021, P. R. China.
Yulin LiangDepartment of Experimental Research, University Engineering Research Center of Oncolytic & Nanosystem Development (Guangxi), Guangxi Medical University Cancer Hospital, Nanning, 530021, P. R. China.
Jiaying TangDepartment of Experimental Research, University Engineering Research Center of Oncolytic & Nanosystem Development (Guangxi), Guangxi Medical University Cancer Hospital, Nanning, 530021, P. R. China.
He DingKey Laboratory of Superlight Materials and Surface Technology, College of Material Sciences and Chemical Engineering, Ministry of Education, Harbin Engineering University, Harbin, 150001, P.R. China. dinghe@hrbeu.edu.cn.
Shufang NingDepartment of Experimental Research, University Engineering Research Center of Oncolytic & Nanosystem Development (Guangxi), Guangxi Medical University Cancer Hospital, Nanning, 530021, P. R. China.
Piaoping YangKey Laboratory of Superlight Materials and Surface Technology, College of Material Sciences and Chemical Engineering, Ministry of Education, Harbin Engineering University, Harbin, 150001, P.R. China. yangpiaoping@hrbeu.edu.cn.
Chen WangDepartment of Experimental Research, University Engineering Research Center of Oncolytic & Nanosystem Development (Guangxi), Guangxi Medical University Cancer Hospital, Nanning, 530021, P. R. China. wangchen88@gxmu.edu.cn.

Funding

Excellent Doctoral Research Project of Guangxi Medical University Cancer Hospital No. 2021-2Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation No. 2024GXNSFBA010139Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation No. 2025GXNSFAA069127National Natural Science Foundation of China No. 82260580Project for Enhancing Young and Middle-aged Teacher's Research Basis Ability in Colleges of Guangxi No. XJ2024010702the Key R&D Program of Scientific Research and Technical Development Project of Qingxiu District, Nanning, Guangxi No. 2021015the Key R&D Program of Scientific Research and Technology Development Project of Guangxi No. Gui Ke AB23026078
6 · The paper itself

Abstract

backgroundFerroptosis, a programmed cell death driven by lipid peroxidation, relies on an oxidative imbalance. However, tumor cells counteract the effects of oxidative imbalance through adaptive defense mechanisms and metabolic reprogramming, thereby limiting the therapeutic efficacy of ferroptosis.

resultsAn antitumor strategy was designed to synergistically induce ferroptosis and apoptosis by targeting the release of nitric oxide (NO) and zinc ions (Zn

conclusionsMulti-pathway disruption of intracellular adaptive defense mechanisms and metabolic reprogramming homeostasis can be achieved via NO synergistic Zn

Indexed as

ApoptosisCalciumFerroptosisNitric OxideZincAnimalsCell Line, TumorEndoplasmic Reticulum StressHumansLipid PeroxidationMiceMitochondriaOxidation-ReductionOxidative StressReactive Oxygen SpeciesCalciumNitric OxideReactive Oxygen SpeciesZincApoptosisCalcium overloadFerroptosisNitric oxideOxidative imbalance

Identifiers

PMID41219739
PMCPMC12606892

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.