Evidence map›Paper›PMID 41219717›Full record

Observational studyBMC medical imaging2025

7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière's disease and endolymphatic hydrops: an exploratory study.

Steve Connor, Peter Lally, Irumee Pai, Haneefah Brnawi, Philip Touska, Sebastien Ourselin, Joseph V Hajnal

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04370366 (Imaging Endolymphatic Hydrops at 7T MRI), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04370366 unknown statusnot on this map

Imaging Endolymphatic Hydrops at 7T MRI: Validation of Internal Inner Ear Structures on T2w Imaging as Markers of Endolymphatic Hydrops and a Comparison of Diagnostic Outcomes With 3T MRI

TypeobservationalSponsorKing's College Hospital NHS TrustRan2023 to 2026Enrolled16ConditionsMeniere Disease
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Steve ConnorSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK. steve.connor@kcl.ac.uk.
Peter LallyDepartment of Bioengineering, Imperial College London, London, W12 0BZ, UK.
Irumee PaiSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Haneefah BrnawiDepartment of Bioengineering, Imperial College London, London, W12 0BZ, UK.
Philip TouskaDepartment of Radiology, Guy's Hospital and St Thomas' Hospital, London, SE1 9RT, UK.
Sebastien OurselinSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Joseph V HajnalSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundWhilst delayed post-gadolinium MRI has led to a shift in the diagnostic paradigm of Meniere's Disease (MD), there remains a strong desire to develop a non-contrast enhanced MRI technique to detect and monitor MD. The endolymphatic space (ES) undergoes hydropic expansion in Ménière's Disease (MD) and the concentration of sodium ions in the endolymph is at least 10 times lower than that in the perilymph. It was hypothesised that the lower sodium (

methodsIn this prospective study, 7T

resultsIn 4 unilateral MD participants (mean age 60.3 years, 2 men), both observers correctly predicted EH laterality in 1/4 before and 3/4 participants after fusion to 3D T2w MRI. There was no incorrect lateralisation of EH by either observer, either before or after registration and fusion. In the 3 participants correctly lateralised, quantitative analysis revealed the median inner ear NaSI scaled to the ipsilateral IAM was 1.2-2.8 times higher in the normal cochlea and 1.9-2.9 times higher in the vestibule, compared to the EH ear. Intraclass correlation coefficient for inner ear median NaSI was 0.70.

conclusionThis exploratory study revealed the potential for severe EH to be qualitatively and quantitatively lateralised with 7T

trial registrationNCT04370366; registered 29/4/20.

Indexed as

Ear, InnerEndolymphatic HydropsMagnetic Resonance ImagingMeniere DiseaseAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedProspective StudiesSodiumSodiumEndolymphatic hydropsMagnetic resonance imagingMeniere’s diseaseSodiumUltra-high-field MRI

Identifiers

PMID41219717
PMCPMC12606957

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.