Evidence map›Paper›PMID 41219596›Full record

ReviewAdvances in experimental medicine and biology2026

Combating Bacterial Infections with Vitamin D-Induced Antimicrobial Peptides.

Nuraly S Akimbekov, Ilya Digel, Kuanysh Tastambek, Rea Rodriguez-Raecke, Atakan Tepecik, Aida S Kistaubayeva, Jian Zha, Mohammed S Razzaque

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nuraly S AkimbekovInternational Center for Islamic Science and Innovation, Al-Farabi Kazakh National University, Almaty, Kazakhstan. Akimbekov.Nuraly@kaznu.edu.kz.
Ilya DigelInstitute for Bioengineering, Aachen University of Applied Sciences, Jülich, Germany.
Kuanysh TastambekInternational Center for Islamic Science and Innovation, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Rea Rodriguez-RaeckeInterdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany.
Atakan TepecikInstitute for Bioengineering, Aachen University of Applied Sciences, Jülich, Germany.
Aida S KistaubayevaInternational Center for Islamic Science and Innovation, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Jian ZhaSchool of Food and Biological Engineering, Shaanxi University of Science and Technology, Shaanxi, Xi'an, China.
Mohammed S RazzaqueUniversity Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Ipoh, Perak, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Owing to emerging global threats such as viral pandemics and the rise of antibiotic resistance, there is an urgent need for novel approaches to combat drug-resistant pathogens. Antimicrobial peptides (AMPs), also known as cationic host defense peptides (CHDPs), are considered promising candidates because of their ability to target various pathogenic microorganisms both directly and indirectly. These functionally versatile molecules modulate host immune responses by activating multiple signaling pathways simultaneously. The unique mechanisms of interaction within the pathogen-host system, combined with relatively straightforward biosynthesis, make AMPs viable alternatives to traditional antibiotics. Vitamin D is a key endogenous factor that regulates the biosynthesis and activity of AMPs, particularly cathelicidin and defensins. This chapter focuses on the interplay between vitamin D and antimicrobial peptides, highlighting recent advances in understanding their synergistic protective effects and potential clinical benefits.

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial InfectionsVitamin DAnimalsBacteriaCathelicidinsHumansAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesCathelicidinsVitamin DAntimicrobial peptideCathelicidinDefensinsInfectionInnate immunityVitamin DVitamin D receptor

Identifiers

PMID41219596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.