ArticleNature structural & molecular biology2025
AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt.
Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Review
- ECLIPSE: exploring the dark proteome of ESKAPE pathogens through the sequence similarity network of the Protein Universe Atlas.Bioinformatics (Oxford, England) · 2026Article
- The transformative impact of AI-enabled AlphaFold 3: evolution, current status, and future prospects in structural biology.Frontiers in artificial intelligence · 2026Review
- Functional annotation of novel heat stress-responsive genes in rice utilizing public transcriptomes and structurome.Bioinformatics advances · 2026Article
- The aging of the AlphaFold database.Nature structural & molecular biology · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
Accurate prediction of protein structures is essential for understanding biological functions and guiding biomedical research. However, maintaining synchronization between structure models and rapidly expanding, continuously evolving protein sequence databases remains a major challenge. Here, we present AlphaSync ( alphasync.stjude.org ), a comprehensive resource that complements the AlphaFold Protein Structure Database. AlphaSync currently provides 2.6 million UniProt-synchronized structural models, including predictions for 40,016 updated proteins and isoforms from 925 species. AlphaSync achieves complete, up-to-date proteome coverage for 42 species, including humans, key pathogens and model organisms. It also provides residue-level annotations such as solvent accessibility, dihedral angles, intrinsic disorder status and over 4.7 billion atom-level noncovalent contacts. Its up-to-date structural models and detailed annotations will facilitate the study of protein structure-function relationships, assessment of sequence variants and machine learning tasks including protein design. With an intuitive web interface and application programming interface, AlphaSync enables protein research at scale and in detail.
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Registered trials
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