Evidence map›Paper›PMID 41219570›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Deep transcranial magnetic stimulation in progressive supranuclear palsy: a randomized double-blind, cross-over study.

Fabiana Giada Radicati, Laura Vacca, Miriam Casali, Ilaria Tremigliozzi, Marika Alborghetti, Martina Lombardi, Paolo Maria Rossini, Fabrizio Stocchi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02734485 (The Use of Deep TMS for the Treatment and Rehabilitation of Patients With Parkinson's Disease and Progressive Supranuclear Palsy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02734485 nacompletednot on this map

The Use of Deep TMS for the Treatment and Rehabilitation of Patients With Parkinson's Disease and Progressive Supranuclear Palsy

TypeinterventionalSponsorIRCCS San Raffaele RomaRan2013 to 2014Enrolled20ConditionsProgressive Supranuclear Palsy, Parkinson's DiseaseArmsactive Deep TMS, sham Deep TMS
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fabiana Giada RadicatiDept. of Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy.
Laura VaccaDept. of Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy.
Miriam CasaliDept. of Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy.
Ilaria TremigliozziDept. of Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy.
Marika AlborghettiDept. of Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy.
Martina LombardiDept. of Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy.
Paolo Maria RossiniDepartment of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy.
Fabrizio StocchiDept. of Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy. fabrizio.stocchi@sanraffaele.it.ORCID http://orcid.org/0000-0002-5763-0033

Funding

Ministero della Salute Ministero della Salute
6 · The paper itself

Abstract

backgroundProgressive supranuclear palsy (PSP) is a rare neuro-degenerative disease. The Deep Transcranial Magnetic Stimulation (DTMS) has been proposed as a therapeutic approach in Parkinson's Disease but there are few studies that have evaluated its efficacy in PSP. AIM AND

methodsThis was a pilot, randomized, cross-over, double blind trial, with the aim to evaluate the effect of DTMS on motor functions, freezing of gait, and cognitive performance in patients with PSP. Nineteen subjects were recruited and randomly assigned to one of the study sequences: real-sham or sham-real. Each cycle consisted of 12 sessions of high frequency DTMS over a 4-week period, separated by a 5-week wash-out period. The targets were the motor cortex and the dorsolateral prefrontal cortex.

resultsAfter adjusting for baseline scores, an interaction effect between DTMS and period of administration emerged for the PSP scale; it was estimated that the real treatment applied to the first period induced a decrease of about 0.79 points (p=0.41) and 4 point (p=0.01) when administered in the second period. Improvement in gait and be relevant since early falls and gait dysfunction have a great impact on disability. Patients and caregivers appreciated the improvements but for a short period of time (about a week).

conclusionThis is the first crossover, double blind, randomized clinical trial to use DTMS in patients with PSP. DMTS was associated with a motor and non-motor improvement in PSP patients.

trial registrationclinicaltrial.gov: NCT02734485.

Indexed as

Supranuclear Palsy, ProgressiveTranscranial Magnetic StimulationAgedCross-Over StudiesDorsolateral Prefrontal CortexDouble-Blind MethodFemaleHumansMaleMiddle AgedMotor CortexPilot ProjectsTreatment OutcomeDeep transcranial magnetic stimulationDorsolateral prefrontal cortexMotor cortexMotor symptomsNon-motor symptomsProgressive supranuclear palsy

Identifiers

PMID41219570

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.