ArticleAnalytical and bioanalytical chemistry2026
Elucidating spatiotemporal distribution of chemical constituents from Corydalis Decumbentis Rhizoma in rat brain via integrated UPLC-MS/MS quantification and DESI-MSI visualization.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tissue pharmacokinetics is crucial for druggability assessment and plays a vital role in identifying the core bioactive components of traditional Chinese medicines (TCMs). This study aims to develop an integrated analytical approach combining ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) to systematically characterize the temporal and spatial brain exposure profiles of Corydalis Decumbentis Rhizoma (CDR) in rats. Using UPLC-quadrupole time of flight mass spectrometry (UPLC-QTOF), a total of 35 drug-derived constituents were identified from rat brain after oral administration of CDR. Then, a rapid and sensitive UPLC-triple-stage quadrupole mass spectrometry (UPLC-TSQ) method was developed and validated for the quantification of 15 major alkaloids in rat brain tissue. The pharmacokinetic results indicated that most compounds reached peak concentrations within 4 h and were rapidly eliminated within 12 h. Tetrahydropalmatine and protopine exhibited notably high brain exposure levels (AUC
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