ReviewPediatric nephrology (Berlin, Germany)2026
Neurodevelopmental outcomes in children with chronic kidney disease: a scoping review.
Review in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Beyond Kidney Function: A Neuro-Renal Perspective on Personalized Care in Pediatric Chronic Kidney Disease.Medical sciences (Basel, Switzerland) · 2026Review
- Neurocognitive and Motor Performance in Pediatric Kidney Transplant Recipients: A Cross-Sectional Controlled Study.Children (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) exhibits unique clinical characteristics in the pediatric population, including growth disturbances and alterations in neurocognitive development. Given the complexity of this condition, it is imperative to adopt comprehensive care strategies that not only address the primary pathology but also mitigate the developmental challenges associated with the disease.
objectiveThe objective was to map and synthesize current scientific evidence regarding the association between CKD and neurodevelopmental outcomes in childhood.
methodsA scoping review was performed using electronic databases -Virtual Health Library (VHL), Medline via PubMed, Scopus, Embase, and Web of Science - to identify studies published between 2014 and 2024. The search strategy utilized a combination of the descriptors "Child Development" AND "Renal Insufficiency, Chronic" to identify relevant studies. The findings were subsequently summarized and qualitatively synthesized.
resultsOf the 2,957 studies identified (2,941 through database searches and 16 through manual searching), 19 specifically examined the implications of CKD on child development and were included in this review. Evidence suggests that children with CKD experience alterations in brain structure and function, including reduced brain volume and compromised structural integrity. These neurological changes appear to be associated with poorer outcomes in both cognitive and motor domains.
conclusionsCKD has systemic and complex effects on the pediatric population, directly impacting neurodevelopment. These findings underscore the importance of early, multidisciplinary strategies to monitor and support neurodevelopment in children with CKD.
Indexed as
Identifiers
41219527What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.