ArticleNature neuroscience2025
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.
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Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28citing papers in PubMed, 1 pooled it
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of a diagnosis-selective neurobiological substrate for bipolar disorder, major depressive disorder, and schizophrenia: a meta-analysis of 57,717 subjects.Psychological medicine · 2026Pooled it
- Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Eating Disorders and Parkinson's Disease-2: Genetic Epidemiology and Shared Genomics.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Folate and global health: part 5. syntheses on neuropsychiatric disorders.Journal of global health · 2026Review
- Identification of comprehensive genetic factors, pathways, and shared genetic architecture of putamen volume in adolescent cohort.Translational psychiatry · 2026Article
- Shared genetic architecture of schizophrenia and Alzheimer's disease and related dementias implicates 16p11.2 and lifespan brain vulnerability.Molecular psychiatry · 2026Article
- Divergent Patterns of Genetic Overlap Between Severe Mental Disorders and Metabolic Markers.The American journal of psychiatry · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- Thalamic nuclei volumes across psychiatric and neurological disorders: a multi-site magnetic resonance imaging study.Translational psychiatry · 2026Article
- Self-Injury Mortality: Global Ascertainment and Prevention.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Review
- Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap.EBioMedicine · 2026Article
- Genetic and Proteomic Investigation of the Smoking-Parkinson's Disease Association.medRxiv : the preprint server for health sciences · 2026Article
- Beyond Exons: Linking Noncoding Heritability and Polygenicity across Complex Human Traits and Disorders.bioRxiv : the preprint server for biology · 2026Article
- Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome-wide mixed methods study.General psychiatry · 2026Article
- Dissecting the genetic relationship between severe mental disorders and autoimmune diseases.Brain, behavior, and immunity · 2026Article
- Eating Disorders and Parkinson's Disease - 2: Population Burden, Genetic Epidemiology and Shared Genomics.medRxiv : the preprint server for health sciences · 2026Article
- Eating Disorders and Parkinson's Disease - 1: Comorbidities, Neurobiology and Family History.medRxiv : the preprint server for health sciences · 2026Article
- Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative Disorders.medRxiv : the preprint server for health sciences · 2025Article
- The Emerging Role of the DDAH Proteins in Psychiatric Disorders.Biological psychiatry global open science · 2025Review
- Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset.Biological psychiatry · 2025Review
Corrections and comments
- Update of
Authors and funding
21 authors.
Olav B SmelandCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. o.b.smeland@medisin.uio.no.ORCID http://orcid.org/0000-0002-3761-5215
Gleda KutrolliCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-6602-2622
Shahram BahramiCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8179-2788
Vera FominykhCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-5490-2390
Nadine ParkerCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8369-0152
Julian FuhrerCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-6286-5614
Guy F L HindleyCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-1666-4701
Linn RødevandCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-5967-6601
Piotr JaholkowskiCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-9408-3107
Markos TesfayeCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-3351-701X
Pravesh ParekhCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-1930-1167
Torbjørn ElvsåshagenCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-9991-1610
Andrew D GrotzingerDepartment of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0001-7852-9244
Nils Eiel SteenCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-6442-1179
Dennis van der MeerCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Kevin S O'ConnellCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Srdjan DjurovicCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8140-8061
Anders M DaleMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6126-2966
Alexey A Shadrin *Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Oleksandr Frei *Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-6427-2625
Ole A AndreassenCentre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ole.andreassen@medisin.uio.no.ORCID http://orcid.org/0000-0002-4461-3568
Funding
OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MHealthy Brain and Child Development National Consortium Data Coordinating CenterU24DA055330 · NIDA · WASHINGTON UNIVERSITY · PI ANDERS M DALE, Damien A Fair · 2021 to 2026
$34.6MThe VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7MDissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3MLarge-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetRF1AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2021 to 2021
$2.1MEC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 801133EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 847776EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 847776, 964874EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 964874EEA Grants (European Economic Area Grants) EEA-RO-NO-2018-0573EEA Grants (European Economic Area Grants) EEA-RO-NO-2018-0573, EEA-RO-NO-2018-0535Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2022073Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2022-087NIA NIH HHS R01 AG076838Norges Forskningsråd (Research Council of Norway) 223273Norges Forskningsråd (Research Council of Norway) 248778Norges Forskningsråd (Research Council of Norway) 273291Norges Forskningsråd (Research Council of Norway) 273446Norges Forskningsråd (Research Council of Norway) 300309Norges Forskningsråd (Research Council of Norway) 324252Norges Forskningsråd (Research Council of Norway) 324499Norges Forskningsråd (Research Council of Norway) 326813Norges Forskningsråd (Research Council of Norway) 344121U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5R01MH124839-02, 1R01MH129742, 1R01MH124839, R01MH123724-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) OT2HL161847U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG076838U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH120219U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1AG073593U.S. Department of Health & Human Services | National Institutes of Health (NIH) U24DA041123U.S. Department of Health & Human Services | National Institutes of Health (NIH) U24DA055330U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH123724-01
Abstract
Although neurological and psychiatric disorders have historically been considered to reflect distinct pathogenic entities, recent findings suggest shared pathophysiological mechanisms. However, the extent to which these heritable disorders share genetic influences remains unclear. Here we performed a comprehensive analysis of genome-wide association study data, involving nearly 1 million cases across ten neurological diseases and ten psychiatric disorders, to compare their common genetic signal and biological associations. Using complementary statistical tools, we demonstrate that a large set of common genetic variants impacts the risk of multiple neurological and psychiatric disorders, even in the absence of genetic correlations. Furthermore, genome-wide association studies on psychiatric disorders consistently implicate neuronal biology, whereas neurological diseases are associated with diverse neurobiological processes. Together, this study elucidates the genetic relationship between complex neurological and psychiatric disorders, indicating a larger degree of genetic pleiotropy than previously recognized. The findings have implications for disease classification, precision medicine and clinical practice.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyMental DisordersNervous System DiseasesHumansPolymorphism, Single Nucleotide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.