Evidence map›Paper›PMID 41219478›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Additive diagnostic value of thoracic SPECT/CT imaging in perugini grade 1 patients who underwent bone scintigraphy.

Michael Poledniczek, René Rettl, Christina Kronberger, Lena Marie Schmid, Nikita Ermolaev, Franz Duca, Christian Nitsche, Christina Binder, Luciana Camuz Ligios, Mahshid Eslami and 10 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. QuantitativeEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Michael PoledniczekDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
René RettlDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Christina KronbergerDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Lena Marie SchmidDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Nikita ErmolaevDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Franz DucaDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Christian NitscheDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Christina BinderDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Luciana Camuz LigiosDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Mahshid EslamiDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Patrick BinderDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria.
Clemens P SpielvogelDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria.
Roza Badr EslamDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Dietrich BeitzkeDivision of Cardiovascular and Interventional Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Johannes KastnerDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Jutta Bergler-KleinDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Andreas A KammerlanderDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Christian HengstenbergDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Marcus HackerDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria.
Raffaella CalabrettaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria. raffaella.calabretta@meduniwien.ac.at.ORCID 0000-0002-8018-3884

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLeft ventricular (LV) myocardial uptake of

methodsWithin the scope of a prospective cardiac amyloidosis registry at the Medical University of Vienna, all patients who underwent bone scintigraphy graded as Perugini grade 1 with additional SPECT/CT imaging performed between September 2014 and May 2025 were retrospectively analysed.

results41 patients (70.8 years, IQR: 64.9-78.8, 41.5% female) were included. The majority (n = 32, 78.0%) of scans were ordered for a suspicion of ATTR-CM. On SPECT/CT images, true LV tracer uptake was confirmed in 4 (9.8%) patients, and 1 (2.4%) patient presented with focal myocardial uptake. In all other patients, tracer uptake was not within the myocardial tissue but rather blood-pool uptake. In follow-up [

conclusionSPECT/CT is mandatory in patients with mild mediastinal tracer uptake interpreted as Perugini grade 1. Among patients with Perugini grade 1 and confirmed [

Indexed as

Amyloid Neuropathies, FamilialBone and BonesCardiomyopathiesSingle Photon Emission Computed Tomography Computed TomographyThoraxAgedFemaleHumansMaleMiddle AgedRetrospective Studies[99mTc]-DPDCardiac amyloidosisLeft ventricular uptake quantificationScintigraphySPECT/CT

Identifiers

PMID41219478
PMCPMC12920355

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.