Evidence map›Paper›PMID 41219464›Full record

ReviewPediatric research2026

Neurological and neurodevelopmental effects of Covid and MIS-C on children.

D Byrne, C Gale, N Canty, J Meehan, D Dumitriu, A Yonts, S B Mulkey, E J Molloy

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D ByrneTrinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
C GaleNeonatal Medicine, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.
N CantyNeonatology, The Coombe Hospital, Dublin, Ireland.
J MeehanDiscipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
D DumitriuDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
A YontsDepartment of Pediatrics, Children's National Hospital, Washington, DC, USA.
S B MulkeyDepartment of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
E J MolloyTrinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. eleanor.molloy@tcd.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been shown to cause a unique disease phenotype in the paediatric population compared to adults, following the emergence of Multisystem Inflammatory Syndrome of Children (MIS-C) and Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS). Over the course of the pandemic, neurological symptoms associated with SARS-CoV-2 have been reported in the paediatric population. The neurological and neurodevelopmental sequelae of both acute SARS-CoV-2 infection and MIS-C/PIMS-TS in the paediatric population are not well understood. Little is known about the underlying pathophysiology and the potential neurovirulence of SARS-CoV-2. Further awareness and research are needed on the neurological sequelae and long-term consequences of SARS-CoV-2 on the developing brain. IMPACT: Detailed review of the current knowledge on neurological and neurodevelopmental effects of SARS-CoV-2 and MIS-C on the paediatric population. Emphasise the importance of acknowledging the potential direct effects of SARS-CoV-2 and MIS-C on neurological and neurodevelopmental outcomes. Highlight the need for further research and inclusion of paediatric patients in follow up studies of long-term effects of SARS-CoV-2 and MIS-C focusing on neurodevelopmental and neurological sequelae.

Indexed as

COVID-19Nervous System DiseasesNeurodevelopmental DisordersSystemic Inflammatory Response SyndromeChildHumansNeurodevelopmentSARS-CoV-2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.