Evidence map›Paper›PMID 41219458›Full record

ArticleNature ecology & evolution2025

Cellular and molecular mechanisms of seahorse male pregnancy.

Yali Liu, Han Jiang, Yuanxiang Miao, Wenli Zhao, Ralf Schneider, Liduo Yin, Xinyue Yu, Haiyan Yu, Xuemei Lu, Enguang Bi and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature ecology & evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yali Liu *CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangdong Provincial Key Laboratory of Applied Marine Biology Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0001-9814-7964
Han Jiang *CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangdong Provincial Key Laboratory of Applied Marine Biology Chinese Academy of Sciences, Guangzhou, China.
Yuanxiang Miao *Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Wenli Zhao *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Ralf SchneiderMarine Evolutionary Ecology, Zoological Institute, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0001-6015-7219
Liduo YinKey Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Xinyue YuCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangdong Provincial Key Laboratory of Applied Marine Biology Chinese Academy of Sciences, Guangzhou, China.
Haiyan YuCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangdong Provincial Key Laboratory of Applied Marine Biology Chinese Academy of Sciences, Guangzhou, China.
Xuemei LuUniversity of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-6044-6002
Enguang BiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Luonan ChenKey Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China. lnchen@sibcb.ac.cn.ORCID http://orcid.org/0000-0002-3960-0068
Axel MeyerCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangdong Provincial Key Laboratory of Applied Marine Biology Chinese Academy of Sciences, Guangzhou, China. axel.meyer@uni-konstanz.de.ORCID http://orcid.org/0000-0002-0888-8193
Qiang LinCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangdong Provincial Key Laboratory of Applied Marine Biology Chinese Academy of Sciences, Guangzhou, China. linqiang@scsio.ac.cn.ORCID http://orcid.org/0000-0002-9916-7761

Funding

CAS | South China Sea Institute of Oceanology, Chinese Academy of Sciences (SCSIO) SCSIO2024QY01National Natural Science Foundation of China (National Science Foundation of China) 42270127National Natural Science Foundation of China (National Science Foundation of China) 42425004, 42230409
6 · The paper itself

Abstract

Seahorses and their relatives (syngnathids) show a unique sex role reversal. Their male pregnancy is facilitated by an evolutionary novel organ-the brood pouch that functions analogously to the mammalian uterus and placenta despite originating from entirely different tissues. Here we use comparative single-cell multiomics and genomics analyses to investigate the transition from egg laying to pregnancy during syngnathid evolution and compare the convergently evolved life history of placental parental care with that in mammals. In vivo experiments show that a population of epithelial progenitors that possesses pouch-inducing potential and expresses androgen, not female hormones as in other live-bearers, can trigger pouch ontogeny. Two mechanisms ensure functionality of the pouch: recruitment of pseudo-placenta-related cells characterized by expressed orthologous genes also found in mammalian uteri and co-option of specific cells for sticky eggs attached to specialized skin patches of males that express novel seahorse-specific genes such as pastns and syn-lectins. These mechanisms combined drove pouch diversity and complexity in syngnathids.

Indexed as

Biological EvolutionSmegmamorphaAnimalsFemaleMalePregnancy

Identifiers

PMID41219458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.