ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025
Role of immunohistochemistry in the molecular classification of atypical teratoid/rhabdoid tumor.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinicopathological Characterization of Pediatric Atypical Teratoid/Rhabdoid Tumors and an HE-IHC Dual-Path Deep Learning Model for Auxiliary Diagnosis.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAtypical teratoid/rhabdoid tumors (ATRTs) are rare, aggressive Central nervous system (CNS) tumors in young children with poor prognosis. Molecular subgrouping (ATRT-TYR, ATRT-SHH, ATRT-MYC) is crucial for understanding biology, guiding treatment, and predicting outcomes. This study assesses immunohistochemistry (IHC) as a surrogate for molecular subgrouping and is the second study to analyze histomorphological patterns across subgroups.
methodsThe study analyzed 39 histopathologically confirmed ATRT cases over 15 years. Clinical and radiological data were obtained from case records, and H&E and IHC slides were reviewed. IHC markers-SOX-11 for ATRT-SHH, C-MYC for ATRT-MYC, and tyrosinase for ATRT-TYR-were used for molecular subgrouping. Subgrouping results were correlated with clinical, pathological, and survival data available in the literature.
resultsThe most common subgroup was ATRT-SHH (41%), followed by ATRT-MYC (33%) and ATRT-TYR (23%). ATRT-SHH predominantly occurred in children ≤ 3 years and showed diverse cell morphology. ATRT-MYC had the widest age range, including adults, and a higher supratentorial prevalence. ATRT-TYR was common in infants and predominantly infratentorial. Rhabdoid cells were the most common cell type, varying across subgroups. Survival analysis (on a limited follow-up cohort of n = 11) suggested ATRT-MYC may be the most aggressive subtype, although this finding is limited by sample size and heterogeneity of treatment.
conclusionImmunohistochemistry (IHC) based classification of ATRT aligned with known molecular and clinicopathological patterns. These alignment with known patterns suggests that the IHC-based classification can be used in routine practice as a cost-effective alternative method to methylation profiling.
Indexed as
Identifiers
41219443What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.