Evidence map›Paper›PMID 41219432›Full record

ArticleNature cell biology2025

Ca

Young-Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Yuka Kamada, Katsuya Iuchi and 23 more

Abstract read
In one paragraph

Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Disulphide maintenance systems and proteostasis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Young-Ho Lee *Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan. mr0505@kbsi.re.kr.ORCID http://orcid.org/0000-0002-8441-5814
Tomohide Saio *Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan. saio@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0003-3639-7399
Mai Watabe *Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Motonori Matsusaki *Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0002-7296-033X
Shingo Kanemura *Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0002-7012-8179
Yuxi Lin *Biopharmaceutical Research Center, Korea Basic Science Institute, Cheongju, Republic of Korea.
Taro Mannen *College of Life Sciences, Ritsumeikan University, Kusatsu, Japan.ORCID http://orcid.org/0000-0002-7227-8509
Tsubura Kuramochi *Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Yuka Kamada *Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, Sanda, Japan.
Katsuya IuchiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Michiko TajiriGraduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.ORCID http://orcid.org/0000-0001-7017-7993
Kotono SuzukiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Yan LiBiopharmaceutical Research Center, Korea Basic Science Institute, Cheongju, Republic of Korea.ORCID http://orcid.org/0000-0001-9043-6390
Yunseok HeoBiopharmaceutical Research Center, Korea Basic Science Institute, Cheongju, Republic of Korea.
Kotone IshiiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Kenta AraiDepartment of Chemistry, School of Science, Tokai University, Hiratsuka, Japan.
Kazunori BanGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Mayuko HashimotoFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Shuichiro OshitaDepartment of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan.ORCID http://orcid.org/0009-0009-5815-0902
Satoshi NinagawaDepartment of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan.
Yoshikazu HattoriInstitute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID http://orcid.org/0000-0002-0013-5584
Hiroyuki KumetaFaculty of Advanced Life Science, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.ORCID http://orcid.org/0000-0003-3713-2122
Airu TakeuchiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Shinji KajimotoGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Hiroya AbeFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0002-8847-1581
Eiichiro MoriDepartment of Future Basic Medicine, Nara Medical University, Kashihara, Japan.ORCID http://orcid.org/0000-0003-0945-196X
Takahiro MuraokaFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0001-6744-048X
Takakazu NakabayashiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0003-2942-2189
Satoko AkashiGraduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Tsukasa OkiyonedaDepartment of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, Sanda, Japan.
Michele VendruscoloDepartment of Chemistry, Centre for Misfolding Disease, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3616-1610
Kenji InabaFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Masaki OkumuraFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan. okmasaki@tohoku.ac.jp.ORCID http://orcid.org/0000-0001-8130-2470

Funding

Japan Agency for Medical Research and Development (AMED) 24gm1410006h9904MEXT | Japan Science and Technology Agency (JST) JPMJFR201FMEXT | Japan Science and Technology Agency (JST) JPMJFR204WMEXT | Japan Science and Technology Agency (JST) JPMJFR2122MEXT | Japan Society for the Promotion of Science (JSPS) 21K19236MEXT | Japan Society for the Promotion of Science (JSPS) 22H04847MEXT | Japan Society for the Promotion of Science (JSPS) 23KK0105MEXT | Japan Society for the Promotion of Science (JSPS) 24K09333National Research Foundation of Korea (NRF) RS-2022-NR069719
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) plays crucial roles in maintaining protein quality control and regulating dynamic Ca

Indexed as

CalciumProcollagen-Proline DioxygenaseProinsulinProtein Disulfide-IsomerasesProtein FoldingAnimalsEndoplasmic ReticulumHEK293 CellsHeLa CellsHumansInsulinOxidation-ReductionProteostasisCalciumInsulinPDIA6 protein, humanProcollagen-Proline DioxygenaseProinsulinProtein Disulfide-Isomerases

Identifiers

PMID41219432
PMCPMC12611771

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.