ArticleNPJ precision oncology2025
A real-world cohort study of immune-related adverse events in patients receiving immune checkpoint inhibitors.
Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical efficacy and safety of pembrolizumab and nivolumab in frontline treatment for classical Hodgkin lymphoma: systematic review and meta-analysis of clinical trials.Frontiers in oncology · 2026Pooled it
- Immune Checkpoint Inhibitors: efficacy, safety, and biomarkers - a systematic review.Frontiers in oncology · 2026Pooled it
- Knowledge and attitudes of family members of cancer patients towards immunotherapy toxicity and health management.Human vaccines & immunotherapeutics · 2026Article
- Delayed and multisystem immune-related adverse events in MSI-high colon cancer treated with nivolumab plus ipilimumab.Clinical journal of gastroenterology · 2026Article
- Immune Checkpoint Inhibitor-Induced Vogt-Koyanagi-Harada-like Disease Complicated by Inflammatory Macular Neovascularisation: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Immune Checkpoint Inhibitor-Related Pneumonitis in Renal Cell Carcinoma: Clinical Features, Mechanisms, and Lessons from Lung Cancer.Biomolecules · 2026Review
- Article
- Co-Formulation of Pembrolizumab Murine Surrogate RMP1-14 with ImagentPharmaceutics · 2026Article
- Heart-Type Fatty Acid-Binding Protein (H-FABP) as a Candidate Adjunctive Biomarker for Immune Checkpoint Inhibitor-Related Cardiotoxicity: Linking Early Immune-Metabolic Myocardial Injury with Translational Cardio-Oncology.International journal of molecular sciences · 2026Review
- Programmed Cell Death Protein 1-Interleukin-2 Bispecific Agents for Cancer Therapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Immunotherapy induced sarcoidosis in a 47-year-old female with stage IIIC cervical cancer on pembrolizumab: A case report.Gynecologic oncology reports · 2026Article
- Reported drug spectrum and disproportionality signals for malignant neoplasm progression in FAERS: a real-world pharmacovigilance study.Frontiers in pharmacology · 2026Article
- A spatiotemporal state-inference framework for adaptive immunotherapy in glioblastoma.Frontiers in oncology · 2026Review
- Drug spectrum and disproportionality signals for diabetes insipidus in FAERS: multi-method analysis, JADER cross-database assessment, and PubMed-based case-level evidence.Frontiers in pharmacology · 2026Article
- Association of endocrine immune-related adverse events with progression-free survival in advanced non-small cell lung cancer treated with PD-1/PD-L1 inhibitors with or without anlotinib.Frontiers in oncology · 2026Article
- Immune checkpoint inhibitor exposure and outcomes of gastrointestinal bleeding in cancer patients: a national analysis of 130,557 hospitalizations, 2018-2022.Frontiers in medicine · 2026Article
- Life-threatening multiorgan immune-related toxicities complicated by sepsis after anti-PD-1 therapy with complete tumor regression: a case report and literature review.Frontiers in immunology · 2026Review
- Dendritic Cell Therapy in Immuno-Oncology: A Potentially Key Component of Anti-Cancer Immunotherapies.Cancers · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Immune checkpoint inhibitors (ICIs) have transformed cancer care but are frequently associated with immune-related adverse events (irAEs), complicating treatment. This retrospective cohort study analyzed 9193 adult patients from the OneFlorida+ Clinical Research Network who received ICIs between 2018 and 2022, aiming to identify risk factors for irAEs and evaluate their incidence, severity, and clinical impact. Among the 6,526 patients included in the final analysis, 56.2% developed irAEs within 1 year, including 284 hospitalized cases. Multivariable logistic regression revealed that younger age (18-29), female sex, and comorbidities such as myocardial infarction, heart failure, and renal disease increased irAE risk, while dementia and recent chemotherapy were associated with lower risk. Patients receiving CTLA-4 + PD(L)1 combination therapy had a 35% higher risk of irAEs than those treated with PD-1 inhibitors alone. Breast and hematologic cancers conferred elevated risk, whereas brain cancer was linked to reduced risk. Kaplan-Meier and cumulative incidence analyses demonstrated that irAE severity significantly impacted time to onset (P = 0.038), and overall survival was worse in patients who developed irAEs (P < 0.0001). Treatment regimen influenced irAE-free survival in multi-site cancers and overall survival in kidney cancer, highlighting the need for tailored irAE risk stratification.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.