Evidence map›Paper›PMID 41219359›Full record

ArticleScientific reports2025

Genetic variants reshape the m

Seung Hun Han, Seongmin Jang, Yeongwon Kim, Kun Tan, Miles F Wilkinson, Hyobin Jeong, Junho Choe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seung Hun HanDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Seongmin JangDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Yeongwon KimDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Kun TanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, San Diego, CA, 92093, USA.
Miles F WilkinsonDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, San Diego, CA, 92093, USA. mfwilkinson@health.ucsd.edu.
Hyobin JeongDepartment of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea. hyobinjeong@yonsei.ac.kr.
Junho ChoeDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea. jcho2711@hanyang.ac.kr.

Funding

Bio&Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) RS-2024-00411768National Research Foundation of Korea (NRF) grants funded by the Korean government (Ministry of Science and ICT) RS-2020-NR050915National Research Foundation of Korea (NRF) grants funded by the Korean government (Ministry of Science and ICT) RS-2024-00336518POSCO Science Fellowship from the POSCO TJ Park Foundation 2024-11-1819
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) associated with various diseases, including cancer. However, the mechanisms by which these SNPs contribute to disease susceptibility remain largely unclear. While recent studies have explored the transcriptional impact of disease-associated SNPs, their role in post-transcriptional regulation has been less extensively investigated. In this study, we investigated whether cancer-associated SNPs influence gene expression by altering N6-methyladenosine (m

Indexed as

AdenosineColorectal NeoplasmsEpigenesis, GeneticGene Expression Regulation, NeoplasticPolymorphism, Single NucleotideTranscriptomeAlkB Homolog 5, RNA DemethylaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansRNA Processing, Post-TranscriptionalAdenosineAlkB Homolog 5, RNA DemethylaseN-methyladenosineAlternative splicingColorectal cancerEpitranscriptomic regulationGenome-wide association studyN6‑methyladenosineSingle-nucleotide polymorphisms

Identifiers

PMID41219359
PMCPMC12606336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.