ArticleScientific reports2025
Ferroptosis biomarkers predict the outcomes of patients with acute ischemic stroke undergoing endovascular thrombectomy.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Targeting ferroptosis and oxidative stress crosstalk: a new frontier in stroke neuroprotection.Journal of molecular histology · 2026Review
- Targeting Ferroptosis and Necroptosis to Treat Stroke.Neurochemical research · 2026Review
- Endothelial ferroptosis in blood-brain barrier dysfunction and neuroinflammation: mechanisms and immune-vascular crosstalk.Frontiers in immunology · 2026Review
- Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions.Experimental biology and medicine (Maywood, N.J.) · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
Ferroptosis contributes to ischemic injury in basic experiments, but the roles of ferroptosis in patients with acute ischemic stroke (AIS) who received reperfusion therapy were unclear. This study prospectively enrolled patients with AIS who underwent endovascular thrombectomy (EVT) and non-stroke controls between February 2019 and May 2023. The plasma levels of three ferroptosis biomarkers-heat shock protein 70 (HSP70), ferritin, and acyl-CoA synthetase long-chain family member 4 (ACSL4)-were measured at pre-EVT, immediately post-EVT, and 24 h post-EVT in stroke patients. Outcomes were assessed using modified Rankin Scale (mRS) score and mortality at 3 months. The study enrolled 150 stroke patients and 50 controls. Stroke patients had higher HSP70 levels than controls. Functional independence (mRS score 0-2) was achieved in 42.5% of 134 followed patients, which was inversely associated with ACSL4 level at 24 h (adjusted odds ratio [aOR] 0.12, 95% confidence interval [CI] 0.03-0.56, P = 0.007) in multivariate logistic regression analyses. Morality occurred in 17.2% of these patients, which was inversely associated with pre-EVT HSP70 level (aOR 0.13, 95% CI 0.02-0.98, P = 0.048). In conclusion, ferroptosis was involved in patients with AIS who underwent EVT, and the plasma levels of ACSL4 and HSP70 were significantly associated with clinical outcomes.
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