Evidence map›Paper›PMID 41219204›Full record

ArticleNPJ Parkinson's disease2025

Inhibition of T cell infiltration and soluble TNF signaling is neuroprotective in the alpha-synuclein overexpressing mouse model of Parkinson's disease.

Adriana Tavira, Leyre Basurco, Miguel Angel Abellanas, Leyre Ayerra, Clara Vidaurre, Esther Luquin, Africa Vales, Gloria Gonzalez-Aseguinolaza, Lucia Marrodan, Marta M Alonso and 4 more

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Adriana Tavira *Departamento de Bioquímica y Genética, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain.
Leyre Basurco *Departamento de Bioquímica y Genética, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain.
Miguel Angel AbellanasDepartamento de Bioquímica y Genética, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain.
Leyre AyerraDepartamento de Bioquímica y Genética, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain.
Clara VidaurreDepartamento de Bioquímica y Genética, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain.
Esther LuquinDepartamento de Patología, Anatomía y Fisiología, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Africa ValesCima-Universidad de Navarra, Pamplona, Spain.
Gloria Gonzalez-AseguinolazaCima-Universidad de Navarra, Pamplona, Spain.
Lucia MarrodanCima-Universidad de Navarra, Pamplona, Spain.
Marta M AlonsoCima-Universidad de Navarra, Pamplona, Spain.
Elisa MengualDepartamento de Patología, Anatomía y Fisiología, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Malú Gámez TanseyDepartment of Neuroscience, College of Medicine, McKnight Brain Institute, Normal Fixel Institute for Neurodegenerative Diseases, University of Florida, Gainesville, FL, USA.
Sandra Hervás-StubbsCima-Universidad de Navarra, Pamplona, Spain.
Maria S AymerichDepartamento de Bioquímica y Genética, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain. maymerich@unav.es.

Funding

Gobierno de Navarra PC 192-193Instituto de Salud Carlos III PI20/01063Ministerio de Ciencia, Innovación y Universidades PID2023-151392OB-I00Ministerio de Universidades FPU018/02244Ministerio de Universidades FPU19/03255Ministerio de Universidades FPU21/01545
6 · The paper itself

Abstract

Modulating the neuroinflammatory response is an emerging and interesting approach for treating Parkinson's disease (PD). In this study, we used an adeno-associated virus (AAV9) to overexpress alpha-synuclein (αSyn) in the substantia nigra pars compacta of mice, inducing a dopaminergic degeneration in a dose-dependent manner. αSyn overexpression was associated with CD4

Identifiers

PMID41219204
PMCPMC12606131

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.