ArticleNature communications2025
A software platform for real-time and adaptive neuroscience experiments.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- AutoNeuro: An Open-Source fMRI Toolbox for Real-Time Neuroadaptive Task Design.bioRxiv : the preprint server for biology · 2026Article
- Computational optimization of two-photon holographic stimulation sitesJournal of neural engineering · 2026Article
- Sardine: A modular framework for developing data acquisition and near real-time analysis applications.PloS one · 2026Article
- Fast photostimulus optimization for holographic control of neural ensemble activitybioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Current neuroscience research is often limited to testing predetermined hypotheses and post hoc analysis of already collected data. Adaptive experimental designs, in which modeling drives ongoing data collection and selects experimental manipulations, offer a promising alternative. However, such adaptive paradigms require tight integration between software and hardware under real-time constraints. We introduce improv, a software platform for flexible integration of modeling, data collection, analysis pipelines, and live experimental control. We demonstrate both in silico and in vivo how improv enables efficient experimental designs for discovery and validation across various model organisms and data types. We used improv to orchestrate real-time behavioral analyses, rapid functional typing of neural responses via calcium imaging, optimal visual stimulus selection, and model-driven optogenetic photostimulation of visually responsive neurons in the zebrafish brain. Together, these results demonstrate the power of improv to integrate modeling with data collection and experimental control to achieve next-generation adaptive experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.