ArticleNature communications2025
Persistent mirusvirus infection in the marine protist Aurantiochytrium.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Genomic catalogue of giant viruses reveals expanded diversity and functional potential.Nature microbiology · 2026Article
- Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling.Nature microbiology · 2026Article
- Hunting for new lineages and mechanisms of life.Nature microbiology · 2026Article
- Revisiting giant virus-host dynamics in brown algae: old stories and new perspectives.The EMBO journal · 2026Review
- Diving into the hidden viral world of marine protists.Journal of virology · 2026Review
- Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes.Nature microbiology · 2026Article
- Genomic, Evolutionary and Phenotypic Insights intoViruses · 2025Article
- Article
- Endogenized polinton-like viruses in the dinoflagellateThe Journal of general virology · 2025Article
- Giant endogenous viral elements in the genome of the model protistJournal of virology · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Mirusviruses are abundant and broadly distributed double-stranded (ds) DNA viruses recently discovered in marine metagenomic data. Their host range and ecological impact are unclear. The protist Aurantiochytrium limacinum possesses two mirusvirus-like genomic elements, one a circular episome (AurliV-1) and the other (AurliV-2) a chromosomal integrant. Here we show that genes in both genomes are expressed and viral particles containing mainly AurliV-1 DNA are produced under starvation conditions and when cells are cultured in standard growth medium. We detected viral particles of ~140 nm in the nucleus, in cytoplasmic vesicles, between the plasma membrane and cell wall, and in the extracellular environment. Of 67 AurliV-1-encoded proteins detected using proteomics, 45 are enriched under starvation conditions, including the structurally important major capsid and triplex proteins. Our results establish Aurantiochytrium as a model system for elucidating mirusvirus-host interactions and demonstrate persistent viral infection in a microbial eukaryote.
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